With the GeneSeeker you can search in different databases simultaneously,
given a known human genetic location and expression/phenotypic pattern. The
GeneSeeker returns any found gene names wich are located on the specified
location and expressed in the specified tissue.
To search for more
expression location in one search, just enter them in the textbox for
the
expression location and separate them with logical operators (and, or,
not). You can specify as many tissues as you want, the program starts 20
queries simultaneously, and then waits for a query to finish before
starting another query, to keep server loads to a minimum.
You can also search only for expression, just leave the cytogenetic location fields blank, and do the query. If you only want to look for one cytogenetic location, only fill in the first location field, and the GeneSeeker will search with only this one.
Housekeeping genes , found
in Swissprot can be excluded, or genes that are to be excluded can be
specified.
Human chromosome localizations are translated with an oxford-grid to mouse
chromosome localizations, and then submitted to the Mgd.
Right now the database that are searched by the GeneSeeker are (if available):
| Expression databases | Cytogenetic databases |
|---|---|
| Omim | Mimmap |
| Medline | Gdb |
| Swissprot (UniProt) | Mgd |
| Trembl (UniProt) | |
| Gxd | |
| Tbase * | |
| Mlc |
The GeneSeeker is developed by
Koen Cuelenaere,
Marc van Driel,
Patrick Kemmeren, Han Brunner and
Jack Leunissen.