Structural alignment:
Results till now
442 structures are aligned (of the 920)
We just added the DAX-1 cluster
Here you can find the alignment of 36 sequences, by using Clustal W and our own alignment.
Please take a look at this three important sites considering the aligment:
1) This site for the last information, how far we are at the moment.
2) Manually adjustments to the alignment can be found here.
3) For a better overview take a look at the complete alignment. Go here.
We have removed all C. elegans sequences, and try to align the 93 left.
Details about the numbering can be found here.
137 150 156 L341 L346 548 560 B250 B254 736 751 848 859 1038 1061
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CONSENSUS AELEELISLLLEAEPETFPAA ADLSLFSSLCELATKQLVHVVEWAKRIPGFRELPLDDQVTLLKAGWMELLILRLAWRSA ADTLLFAA AGLTLNREQLKNAA AFGELFDRIFAELASKLRALQLDDEEFACLKAIILLSA AVEKVEKLQEKLLAALEHYIRKRRA AQRFAKLLLKLPDIRSISAKHAEHLA APPLLLEML
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328 353 447 458 B150 B155 647 653 L781 L785 936 958 1245 1252
Profile: hRXRa (based on 3D structure) Number of sequences aligned: 69
137 150 156 L341 L346 548 560 B250 B254 736 751 848 859 1038 1061
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RXRA_HUMAN SANEDMPVERILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPAEVEALREKVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
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328 353 447 458 B150 B155 647 653 L781 L785 936 958 1245 1252
RXRA_MOUSE SANEDMPVEKILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPAEVEALREKVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
RXRA_RAT SANEDMPVEKILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPAEVEALREKVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
RXRA_XENLA SANEDMPVEKILEAEHAVEPKT.sPSDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPLEVEALREKVYASLEAYCKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
Q90418 AANEEMPVEKILEAEMAVEQKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELSLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG.eVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIILFNP.sPSEVELLREKVYASLEAYCKQRYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
Q90415 CANEDMPVEKILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHTAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPSEVEALRERVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
RXRB_HUMAN saPEEMPVDRILEAELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPSEVEVLREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
RXRB_MOUSE saPEEMPVDRILEAELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGEVEILREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
RXRB_RAT GAPEEMPVDRILEAELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGEVEILREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
Q91840 AINEEMPVEKILEAELAVEQKS.sPSDPVTNICQAADKQLFTLVEWAKRIPHFSELALDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGDVEVLREKVYASLESYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
RXRA_BRARE SFNEEMPVEKILDAELAVEPKT.sTNDPVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSV.kDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPSEVEALREKVYASLEGYTKHNYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
RXRG_CHICK GGSEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP.sPSEVESLREKVYATLEAYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
RXRG_HUMAN SGHEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP.nPSEVETLREKVYATLEAYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
Q91613 AINEEMPVEKILEAELAVEQKS.sPSDPVTNICQDADKQLFTLVEWAKRIPHfpELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFERVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGDVEVLREKVYACLESYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
RXRG_MOUSE SSHEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP.nPSEVETLREKVYATLEAYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDSFLMEML.
RXRG_XENLA atSEEMPVERILEAELAVDPKI.sTNDPVTNICHAADKQLFTLVEWAKRIPYFSDLPLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHNAG..VGSIFDRVLTELVSKMKDMDMDKSELGCLRAIVLFNP.nAAEVEALREKVYATLESYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
Q90417 SANEEMPVEKILEAETAVEHRT.sPNDPVTNICQAADKQLFTLVEWAKRVPHFSDVPLDDQVILLRAGWNELLIAAFSHRSI.kDEILLAT..GLHVPKESTHNLG.eVGALFDRVLTELVCKMRDMQMDKTELGCLRAIVLFNP.sSSEVELLREKVYASLESYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
Q9UAF1 spNDDMPVDKILEAELISDPKV.nENDPVSNICKAADRQLVTLVEWAKRIPHFSSLPLEDQVILLRAGWNELLIASFSHRSI.kDSILLAS..GLHVHRHSAHQAG..VGPIFDRVLTELVSKMRDMMMDKTELGCLRAIVLFNP.dSAHIESLREKVYASLEAYCRSKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDKFLMNML.
Q06310 .............AELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG.iFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPSEVEVLREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.
Q64116 sgHEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMRMDKSELGCLRAIVLFNP.nPSEVETLREKVYATL...............................................
Q9NG48 SLHSDMPIERILEAEKRVECKM.nYENAVSHICNATNKQLFQLVAWAKHIPHFTSLPLEDQVLLLRAGWNELLIASFSHRSI.kDGIVLAT..GITVHRNSAQQAG..VGTIFDRVLSELVSKMREMKMDRTELGCLRSIILFNP.sIQEVTLLREKIYGALEGYCRVAWP.aGRFAKLLLRLPAIRSIGLKCLEYLF.iDDFLVEML.
Q9U7D9 SLHTDMPVERILEAEKRVECKA.............ENQVEYELVEWAKHIPHFTSLPLEDQVLLLRAGWNELLIAAFSHRSV.kDGIVLAT..GLTVHRNSAHQAG..VGTIFDRVLTELVAKMREMKMDKTELGCLRSVILFNP.sAQEVELLREKVYAALEEYTRTTHP.pGRFAKLLLRLPSLRSIGLKCLEHLF.iDTFLMEML.
O61448 aaPPEMPLERILEAELRVESQT.qQQDPVSSICQAADRQLHQLVQWAKHIPHFEELPLEDRMVLLKAGWNELLIAAFSHRSV.rDGIVLAT..GLVVQRHSAHGAG..VGAIFDRVLTELVAKMREMKMDRTELGCLLAVVLFNP.rTCPSGGPEGESVSALEEHCRQQYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDNFLLSML.
O61449 agSPDMPLERILEAEMRVEQPA.aSGRDPVNSMCQAAPPLHELVQWARRIPHFEELPIEDRTALLKAGWNELLIAAFSHRSV.rDGIVLAT..GLVVQRHSAHGAG..VGDIFDRVLAELVAKMRDMKMDKTELGCLRAVVLFNP.nATRVEALREKVYAALEEHCRRHHP.pGRFGKLLLRLPALRSIGLKCLEHLF.iDSFLLNML.
Q9NFY1 NMQAEMPLDRIIEAEKRIECTP.eQHDGVNNICQATNKQLFQLVQWAKLIPHFTSLPMSDQVLLLRAGWNELLIAAFSHRSI.qDAIVLAT..GLTVNKTSAHAVG..VGNIYDRVLSELVNKMKEMKMDKTELGCLRAIILYNP.sVQEVEMLREKIYGVLEEYTRTTHP.pGRFAKLLLRLPALRSIGLKCSEHLF.iDTFLMEML.
O76241 saISDMPIASIREAELSVDPID.pLQDVVSNICQAADRHLVQLVEWAKHIPHFTDLPIEDQVVLLKAGWNELLIASFSHRSM.eDGIVLAT..GLVIHRSSAHQAG..VGAIFDRVLSELVAKMKEMKIDKTELGCLRSIVLFNP.cVNDVEILREKVYAALEEYTRTTYP.pGRFAKLLLRLPALRSIGLKCLEYLF.lDSYLMKMLV
O45117 GPGRDITVERLMEADQMSEARC.eYRAPVSAICAMVNKQVFQHMDFCRRLPHFTKLPLNDQMYLLKQSLNELLILNIAYMSI.aDGSLERR.rNYTLGRNMAVQAG..VVQIFDRILSELSVKMKRLDLDATELCLLKSIVVFNP.dRKSIDLLRSRIYASLDEYCRQKHP.dGRFAQLLLRLPALRSISLKCLDHLF.vENSVIEEFH
O96562 adLPMIPIESIIAAETLVDPGI.aNTDPIRHVCLAADKQLASLAEWAKRLPHFRDLSIADQVVLLQWSWPELLIGGFCHRSC.kDGILLST..GLHLTRDNLKKAG..VGAIIDKIFSEVIEKMQEIQMDRAEWGCLRAIMLFSP.aIDQVENYRELYTSTLEDHVKRKHP.pDRFTKVILRIPALKSIGLQALEHLY.mDTFLLDML.
Q91430 asYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
COT2_MOUSE asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
COT2_BOVIN asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
COT2_CHICK asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
COT2_RAT asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
COT2_HUMAN asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
COT1_BOVIN acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
COT1_HUMAN acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
COT1_MOUSE acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
Q9W745 acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCIKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
Q9PS79 asYLSGYISLVLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLSAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
SV44_BRARE acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCIKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
Q62681 acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vA.VLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL
Q9BMU6 gsYLSSYISLLLRAEPYPTSRY.nNIMGIDNICELAARLLFSAVEWARNIPFFPDLQVTDQVALLRLVWSELFVLNASQCSM.vAPLLAA..AGLHASPMAADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT.dVAHIESLQEKSQCALEEYCRSQYP.pTRFGKLLLRLPSLRTVSSQVIEQFF.iETLIRDMLL
7UP1_DROME csYLSSYISLLLRAEPYPTSRY.nNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSM.vAPLLAA..AGLHASPMAADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT.dVTHIESLQEKSQCALEEYCRTQYP.pTRFGKLLLRLPSLRTVSSQVIEQLF.iETLIRDMLL
SV46_BRARE apYLSGFISLLLRAEPYPTSRY.nNLMGIENICELAARLLFSAVEWAKNIPFFPDLQLMDQVALLRMSWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSAERVV..AFMDHIRVFQEQVEKLKALQVDTAEYSCLKSIVLFTS.dVAHVESIQEKSQCALEEYVRNQYP.pNRFGRLLLRLPSLRIVSSPVIEQLF.iETLLRDMLL
Q91720 asYLTGFISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAIEWAKNIPFFPDFQLSDQVSLLRMTWSELFVLNAAQCSM.vAPLLAR..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIALFTP.dIGHVESIQEKSQCALEEYVRNQYP.pTRFGRLLLRLPSLRIVSAPVIEQLF.iETLIRDMLL
7UP2_DROME csYLSSYISLLLRAEPYPTSRY.nNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSM.vAPLLAA..AGLHASPMAADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT................................................................
Q9BUE8 aqPVSELIAQLLRAEPYPAAAG.gAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAAL.tAPLLAA..AGLHAAPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISQLF.iETLIRDMLL
EAR2_HUMAN aqPVSELIAQLLRAEPYPAAAG.gAVLGIDNVCELAARLLFSTVEWARH.GFFPELPVADQVALLRMSWSELFVLNAAQAAL.tAPLLAA..AGLHAAPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISQLF.iETLIRDMLL
EAR2_MOUSE apPVSELIAQLLRAEPYPAAGR.gAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVALLRLSWSELFVLNAAQAAL.tAPLLAA..AGLHAAPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISKLF.iETLIRDMLL
EAR2_RAT apPVSELIAQLLRAEPYPAAGR.gAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVGLLRLSWSELFVLNAAQAPV.tAPLLAA..AGLHAGPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISQLF.iETLIRDMLL
Q9GSG7 SSVRDVTIERIHEAEQLSEQKS.eYKGAVSHLCQMVNKQIYQLIDFARRVPHFINLPRDDQVMLLRCGWNEMLIAAVAWRSM.qLMCLGP...NFTLHRNSAQQAG..VDTLFDRILCELGIKMKRLDVTRAELGVLKAIILFNP.cQKEIDGMREKIYACLDEHCKQQHP.dGRFAQLLLRLPALRSISLKCLDHLN.lDSFIVEML.
Q9GSG8 SSVRDVTIERIHEAEQLSEQKS.eYKGAVSHLCQMVNKQIYQLIDFARRVPHFINLPRDDQVMLLRCGWNEMLIAAVAWRSM.qLMCLGP...NFTLHRNSAQQAG..VDTLFDRILCELGIKMKRLDVTRAELGVLKAIILFNP.cQKEIDGMREKIYACLDEHCKQQHP.dGRFAQLLLRLPALRSISLKCLDHLN.lDSFIVEML.
Q9U3Y3 SSVRDVTIERITAAEQLSEQKS.eYKGAVSHLCQMVNKQIYQLIDFARRLPHFTNLHRDDQVMLLRCGWNEMLIAAVAWRSM.qLMCLGP...NFTLHRNSAQQAG..VDTLFDRILCELGIKMKRLDVTRAELGVLKAIILFNP.cQNGDDGMREKIYACLDEHCKQQHP.dGRFAQLLLRLPALRSISLKCLDHLN.lDNFIIEML.
USP_CHOFU svSDELSIERLTEMESLVADPS.rYRAPVSSLCQIGNKQIAALVVWARDIPHFGQLELDDQVVLIKASWNELLLFAIAWRSM.qLMCLMP...GMTLHRNSAQQAG..VGAIFDRVLSELSLKMRTLRMDQAEYVALKAIVLLNP.nRQEVDVLREKMFSCLDDYCRRSRS.eGRFASLLLRLPALRSISLKSFEHLY.iSGYIREAL.
USP_MANSE SSVQELSIERLLEIESLVADPP.kYRAPVSSLCQIGNKQIAALVVWARDIPHFGQLELEDQILLIKNSWNELLLFAIAWRSM.qLMCLMP...GMTLHRNSALQAG..VGQIFDRVLSELSLKMRTLRMDQAEYVALKAIILLNP.nKPEVVVLREKMFSCLDEYVRRSRC.eGRFAALLLRLPALRSISLKCFEHLY.iASYIHDAL.
USP_BOMMO SSVQELSIERLLELEALVADSA.kYRAPVSSLCQIGNKQIAALIVWARDIPHFGQLEIDDQILLIKGSWNELLLFAIAWRSM.qLICLMP...GMTLHRNSALQAG..VGQIFDRVLSELSLKMRSLRMDQAECVALKAIILLNP.nKQEVDVLREKMFLCLDEYCRRSRG.eGRFAALLLRLPALRSISLKSFEHLY.vSSYIRDAL.
USP_DROME SVSRDFSIERIIEAEQRAETQC.dYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSI.pQQLFLNQ..SFSYHRNSAIKAG..VSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNP.sRAEIEMCREKVYACLDEHCRLEHP.dGRFAQLLLRLPALRSISLKCQDHLF.sDRPLEELF.
HN4A_MOUSE adSSLPSINALLQAEVLSQQIT.kKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL
HN4A_RAT adSSLPSINALLQAEVLSQQIT.kKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL
Q9JJI9 adSSLPSINALLQAEVLSQQIT.kKIANIADVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL
HN4A_HUMAN adSSLPSINALLQAEVLSRQIT.kKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL
HN4A_XENLA adSSLPSINVLIQAEVLSQQIT.kKIACIIDVCDSMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDILLLGN..DRLIPRNCPELEV...GRVAVRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPTKIKRMRYQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL
HN4G_MOUSE ngSNIPSINTLAQAEVRSCQIS.kKIASISDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDILLLGN..HYVIHRNSCEVEV...SRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDP.dPVKIKNMRFQVQISLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL
HN4G_HUMAN ngSNIPSINTLAQAEVRSRQIS.kKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDILLLGN..NYVIHRNSCEVEI...SRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDP.dPVKIKNMRFQVQIGLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL
HN4B_XENLA tdNGSLSINVLTQAEAMVHQYS.kKVASISDVCESMKQQLLLLVEWAKYIPAFCELPLDDQVALLRAHAGAHLLLGVAKRSL.kDFLLLGN..DFIMPMHCPELEI...ARVPCRILDELVKPLREIQIDDNEYVCLKAIIFFDP.dQTKVKNMRFQVQVNLEDYINDRQF.rGRFSDILLLLPPLQSITWQMIEQVQ.iDSLLQELLL
HNF4_DROME apGNGLSVISLVKAENESRQSK.kQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSM.kDVLLLSN..NCVITRHCPDPLV.dISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDP.ePHRIKSLRHQILNNLEDYISDRQY.rGRFGEILLILPVLQSITWQMIEQIQ.iDSLLQEMLL
O97120 sdLPNLTLRCLLSAELSMDPKL.tGLHPLTIICQSIEQQLPRIVNWARQLPVFSslSFDDQFCLIKAAWPELVLISSAYHST.rDGLLLSI..GRHLGREVAKSHG..LGPLVDRILHELVARFRDLSLQRTELALLRAIILFNP.sRHRVEAVREQLYSALHSYCTTNQP.tSRFTKLLLRLPPLRSIASKCLEHLV.iQEKSFELAT
O77099 stSNGLSVKFLLLAENRSRHFG.kRFASINDVCDSMKQQLLILVEWAKSIPAFAELQLDDQVALLRAHAGEHLLLGLSRRSM.eEMLLLGN..NCIITKQSPDSKM.dISRIGARIIDELVSAIKDIKLDDSELACIKALVFFDP.qPQKIKALRHQVLNNLEDYVSDKQY.rGRFGEILLLLPVLQSITWQMIQQIE.iDSLLQEMLL
O46174 sqANGLSVVSLLNAELLSRKVI.rKLAKINDVCDSIKQQLLILVEWAKYIPAFTVLHLDDQVALLRAHAGEHLLLGCARRSL.kDILLLGN..NCIITKHNIDGRM.dISMIGMRVMDEIVKPLREIDIDDTEFACLKAIVFFDP.qPQKIKQLRYQIQINLEDYISDRQY.rGRFGELLLCLPPLQSITWQMIEQIQ.vDSLLQEMLL
Profile: hERa (based on 3D structure) Number of sequences aligned: 50
137 150 156 L341 L346 548 560 B250 B254 736 751 848 859 1038 1061
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ESR1_HUMAN SLTADQMVSALLDAEPPILYSE.sEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TSSRFRMMNLQGEEFVCLKSIILLNS.eKDHIHRVLDKITDTLIHLMAKAGL.hQRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.
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328 353 447 458 B150 B155 647 653 L781 L785 936 958 1245 1252
ESR2_BOVIN ALSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLYDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..DLILDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sGRKLTHLLNAVTDALVWVIAKSGM.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN
Q9BDW5 slSPEQLVLTLLEAEPPHVLVS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLYDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLTHLLNAVTDALVWVIARSGI.sVRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN
ESR2_HUMAN slSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLAHLLNAVTDALVWVIAKSGI.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN
ESR2_SHEEP ALSPEQLVLTLLEAEPPHVLMS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLYDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sGRKLTHLLNAVTDALVWVIAKSGM.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN
ESR2_RAT slSPEQLVLTLLEAEPPNVLVS.tEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLTHLLNAVTDALVWVIAKSGI.sVRLANLLMLLSHVRHISNKGMEHLL.vYDLLLEMLN
ESR2_MACMU ALSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRL