Structural alignment:
Results till now 
442 structures are aligned (of the 920)

We just added the DAX-1 cluster

Here you can find the alignment of 36 sequences, by using Clustal W and our own alignment.


Please take a look at this three important sites considering the aligment:

1) This site for the last information, how far we are at the moment.
2) Manually adjustments to the alignment can be found here.

3) For a better overview take a look at the complete alignment. Go here.

We have removed all C. elegans sequences, and try to align the 93 left.

Details about the numbering can be found here.

                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
CONSENSUS           AELEELISLLLEAEPETFPAA ADLSLFSSLCELATKQLVHVVEWAKRIPGFRELPLDDQVTLLKAGWMELLILRLAWRSA ADTLLFAA AGLTLNREQLKNAA AFGELFDRIFAELASKLRALQLDDEEFACLKAIILLSA AVEKVEKLQEKLLAALEHYIRKRRA AQRFAKLLLKLPDIRSISAKHAEHLA APPLLLEML  
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252


Profile: hRXRa (based on 3D structure) Number of sequences aligned: 69



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
RXRA_HUMAN         SANEDMPVERILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPAEVEALREKVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252

RXRA_MOUSE         SANEDMPVEKILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPAEVEALREKVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRA_RAT           SANEDMPVEKILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPAEVEALREKVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRA_XENLA         SANEDMPVEKILEAEHAVEPKT.sPSDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPLEVEALREKVYASLEAYCKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q90418             AANEEMPVEKILEAEMAVEQKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELSLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG.eVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIILFNP.sPSEVELLREKVYASLEAYCKQRYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q90415             CANEDMPVEKILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHTAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPSEVEALRERVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRB_HUMAN         saPEEMPVDRILEAELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPSEVEVLREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRB_MOUSE         saPEEMPVDRILEAELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGEVEILREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRB_RAT           GAPEEMPVDRILEAELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGEVEILREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q91840             AINEEMPVEKILEAELAVEQKS.sPSDPVTNICQAADKQLFTLVEWAKRIPHFSELALDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGDVEVLREKVYASLESYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRA_BRARE         SFNEEMPVEKILDAELAVEPKT.sTNDPVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSV.kDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPSEVEALREKVYASLEGYTKHNYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRG_CHICK         GGSEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP.sPSEVESLREKVYATLEAYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRG_HUMAN         SGHEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP.nPSEVETLREKVYATLEAYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q91613             AINEEMPVEKILEAELAVEQKS.sPSDPVTNICQDADKQLFTLVEWAKRIPHfpELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFERVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGDVEVLREKVYACLESYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRG_MOUSE         SSHEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP.nPSEVETLREKVYATLEAYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDSFLMEML.                                                                                                     
RXRG_XENLA         atSEEMPVERILEAELAVDPKI.sTNDPVTNICHAADKQLFTLVEWAKRIPYFSDLPLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHNAG..VGSIFDRVLTELVSKMKDMDMDKSELGCLRAIVLFNP.nAAEVEALREKVYATLESYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q90417             SANEEMPVEKILEAETAVEHRT.sPNDPVTNICQAADKQLFTLVEWAKRVPHFSDVPLDDQVILLRAGWNELLIAAFSHRSI.kDEILLAT..GLHVPKESTHNLG.eVGALFDRVLTELVCKMRDMQMDKTELGCLRAIVLFNP.sSSEVELLREKVYASLESYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q9UAF1             spNDDMPVDKILEAELISDPKV.nENDPVSNICKAADRQLVTLVEWAKRIPHFSSLPLEDQVILLRAGWNELLIASFSHRSI.kDSILLAS..GLHVHRHSAHQAG..VGPIFDRVLTELVSKMRDMMMDKTELGCLRAIVLFNP.dSAHIESLREKVYASLEAYCRSKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDKFLMNML.                                                                                                     
Q06310             .............AELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG.iFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPSEVEVLREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q64116             sgHEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMRMDKSELGCLRAIVLFNP.nPSEVETLREKVYATL...............................................                                                                                                     
Q9NG48             SLHSDMPIERILEAEKRVECKM.nYENAVSHICNATNKQLFQLVAWAKHIPHFTSLPLEDQVLLLRAGWNELLIASFSHRSI.kDGIVLAT..GITVHRNSAQQAG..VGTIFDRVLSELVSKMREMKMDRTELGCLRSIILFNP.sIQEVTLLREKIYGALEGYCRVAWP.aGRFAKLLLRLPAIRSIGLKCLEYLF.iDDFLVEML.                                                                                                     
Q9U7D9             SLHTDMPVERILEAEKRVECKA.............ENQVEYELVEWAKHIPHFTSLPLEDQVLLLRAGWNELLIAAFSHRSV.kDGIVLAT..GLTVHRNSAHQAG..VGTIFDRVLTELVAKMREMKMDKTELGCLRSVILFNP.sAQEVELLREKVYAALEEYTRTTHP.pGRFAKLLLRLPSLRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
O61448             aaPPEMPLERILEAELRVESQT.qQQDPVSSICQAADRQLHQLVQWAKHIPHFEELPLEDRMVLLKAGWNELLIAAFSHRSV.rDGIVLAT..GLVVQRHSAHGAG..VGAIFDRVLTELVAKMREMKMDRTELGCLLAVVLFNP.rTCPSGGPEGESVSALEEHCRQQYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDNFLLSML.                                                                                                     
O61449             agSPDMPLERILEAEMRVEQPA.aSGRDPVNSMCQAAPPLHELVQWARRIPHFEELPIEDRTALLKAGWNELLIAAFSHRSV.rDGIVLAT..GLVVQRHSAHGAG..VGDIFDRVLAELVAKMRDMKMDKTELGCLRAVVLFNP.nATRVEALREKVYAALEEHCRRHHP.pGRFGKLLLRLPALRSIGLKCLEHLF.iDSFLLNML.                                                                                                     
Q9NFY1             NMQAEMPLDRIIEAEKRIECTP.eQHDGVNNICQATNKQLFQLVQWAKLIPHFTSLPMSDQVLLLRAGWNELLIAAFSHRSI.qDAIVLAT..GLTVNKTSAHAVG..VGNIYDRVLSELVNKMKEMKMDKTELGCLRAIILYNP.sVQEVEMLREKIYGVLEEYTRTTHP.pGRFAKLLLRLPALRSIGLKCSEHLF.iDTFLMEML.                         
O76241             saISDMPIASIREAELSVDPID.pLQDVVSNICQAADRHLVQLVEWAKHIPHFTDLPIEDQVVLLKAGWNELLIASFSHRSM.eDGIVLAT..GLVIHRSSAHQAG..VGAIFDRVLSELVAKMKEMKIDKTELGCLRSIVLFNP.cVNDVEILREKVYAALEEYTRTTYP.pGRFAKLLLRLPALRSIGLKCLEYLF.lDSYLMKMLV                                                                                                          
O45117             GPGRDITVERLMEADQMSEARC.eYRAPVSAICAMVNKQVFQHMDFCRRLPHFTKLPLNDQMYLLKQSLNELLILNIAYMSI.aDGSLERR.rNYTLGRNMAVQAG..VVQIFDRILSELSVKMKRLDLDATELCLLKSIVVFNP.dRKSIDLLRSRIYASLDEYCRQKHP.dGRFAQLLLRLPALRSISLKCLDHLF.vENSVIEEFH                             
O96562             adLPMIPIESIIAAETLVDPGI.aNTDPIRHVCLAADKQLASLAEWAKRLPHFRDLSIADQVVLLQWSWPELLIGGFCHRSC.kDGILLST..GLHLTRDNLKKAG..VGAIIDKIFSEVIEKMQEIQMDRAEWGCLRAIMLFSP.aIDQVENYRELYTSTLEDHVKRKHP.pDRFTKVILRIPALKSIGLQALEHLY.mDTFLLDML.                                                                     
Q91430             asYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_MOUSE         asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_BOVIN         asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_CHICK         asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_RAT           asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_HUMAN         asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT1_BOVIN         acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT1_HUMAN         acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT1_MOUSE         acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
Q9W745             acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCIKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
Q9PS79             asYLSGYISLVLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLSAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
SV44_BRARE         acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCIKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
Q62681             acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vA.VLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
Q9BMU6             gsYLSSYISLLLRAEPYPTSRY.nNIMGIDNICELAARLLFSAVEWARNIPFFPDLQVTDQVALLRLVWSELFVLNASQCSM.vAPLLAA..AGLHASPMAADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT.dVAHIESLQEKSQCALEEYCRSQYP.pTRFGKLLLRLPSLRTVSSQVIEQFF.iETLIRDMLL                                                                                                     
7UP1_DROME         csYLSSYISLLLRAEPYPTSRY.nNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSM.vAPLLAA..AGLHASPMAADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT.dVTHIESLQEKSQCALEEYCRTQYP.pTRFGKLLLRLPSLRTVSSQVIEQLF.iETLIRDMLL                                                                                                     
SV46_BRARE         apYLSGFISLLLRAEPYPTSRY.nNLMGIENICELAARLLFSAVEWAKNIPFFPDLQLMDQVALLRMSWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSAERVV..AFMDHIRVFQEQVEKLKALQVDTAEYSCLKSIVLFTS.dVAHVESIQEKSQCALEEYVRNQYP.pNRFGRLLLRLPSLRIVSSPVIEQLF.iETLLRDMLL                                                                                                     
Q91720             asYLTGFISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAIEWAKNIPFFPDFQLSDQVSLLRMTWSELFVLNAAQCSM.vAPLLAR..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIALFTP.dIGHVESIQEKSQCALEEYVRNQYP.pTRFGRLLLRLPSLRIVSAPVIEQLF.iETLIRDMLL                                                                                        
7UP2_DROME         csYLSSYISLLLRAEPYPTSRY.nNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSM.vAPLLAA..AGLHASPMAADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT................................................................                                                                                 
Q9BUE8             aqPVSELIAQLLRAEPYPAAAG.gAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAAL.tAPLLAA..AGLHAAPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISQLF.iETLIRDMLL                                                                                                     
EAR2_HUMAN         aqPVSELIAQLLRAEPYPAAAG.gAVLGIDNVCELAARLLFSTVEWARH.GFFPELPVADQVALLRMSWSELFVLNAAQAAL.tAPLLAA..AGLHAAPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISQLF.iETLIRDMLL                                                                                                     
EAR2_MOUSE         apPVSELIAQLLRAEPYPAAGR.gAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVALLRLSWSELFVLNAAQAAL.tAPLLAA..AGLHAAPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISKLF.iETLIRDMLL                                                                                                     
EAR2_RAT           apPVSELIAQLLRAEPYPAAGR.gAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVGLLRLSWSELFVLNAAQAPV.tAPLLAA..AGLHAGPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISQLF.iETLIRDMLL                                                                                          
Q9GSG7             SSVRDVTIERIHEAEQLSEQKS.eYKGAVSHLCQMVNKQIYQLIDFARRVPHFINLPRDDQVMLLRCGWNEMLIAAVAWRSM.qLMCLGP...NFTLHRNSAQQAG..VDTLFDRILCELGIKMKRLDVTRAELGVLKAIILFNP.cQKEIDGMREKIYACLDEHCKQQHP.dGRFAQLLLRLPALRSISLKCLDHLN.lDSFIVEML.                                                                                                     
Q9GSG8             SSVRDVTIERIHEAEQLSEQKS.eYKGAVSHLCQMVNKQIYQLIDFARRVPHFINLPRDDQVMLLRCGWNEMLIAAVAWRSM.qLMCLGP...NFTLHRNSAQQAG..VDTLFDRILCELGIKMKRLDVTRAELGVLKAIILFNP.cQKEIDGMREKIYACLDEHCKQQHP.dGRFAQLLLRLPALRSISLKCLDHLN.lDSFIVEML.                                                                                                     
Q9U3Y3             SSVRDVTIERITAAEQLSEQKS.eYKGAVSHLCQMVNKQIYQLIDFARRLPHFTNLHRDDQVMLLRCGWNEMLIAAVAWRSM.qLMCLGP...NFTLHRNSAQQAG..VDTLFDRILCELGIKMKRLDVTRAELGVLKAIILFNP.cQNGDDGMREKIYACLDEHCKQQHP.dGRFAQLLLRLPALRSISLKCLDHLN.lDNFIIEML.                                                                                                     
USP_CHOFU          svSDELSIERLTEMESLVADPS.rYRAPVSSLCQIGNKQIAALVVWARDIPHFGQLELDDQVVLIKASWNELLLFAIAWRSM.qLMCLMP...GMTLHRNSAQQAG..VGAIFDRVLSELSLKMRTLRMDQAEYVALKAIVLLNP.nRQEVDVLREKMFSCLDDYCRRSRS.eGRFASLLLRLPALRSISLKSFEHLY.iSGYIREAL. 
USP_MANSE          SSVQELSIERLLEIESLVADPP.kYRAPVSSLCQIGNKQIAALVVWARDIPHFGQLELEDQILLIKNSWNELLLFAIAWRSM.qLMCLMP...GMTLHRNSALQAG..VGQIFDRVLSELSLKMRTLRMDQAEYVALKAIILLNP.nKPEVVVLREKMFSCLDEYVRRSRC.eGRFAALLLRLPALRSISLKCFEHLY.iASYIHDAL.                                                                                                     
USP_BOMMO          SSVQELSIERLLELEALVADSA.kYRAPVSSLCQIGNKQIAALIVWARDIPHFGQLEIDDQILLIKGSWNELLLFAIAWRSM.qLICLMP...GMTLHRNSALQAG..VGQIFDRVLSELSLKMRSLRMDQAECVALKAIILLNP.nKQEVDVLREKMFLCLDEYCRRSRG.eGRFAALLLRLPALRSISLKSFEHLY.vSSYIRDAL.                                                                                                                                             
USP_DROME          SVSRDFSIERIIEAEQRAETQC.dYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSI.pQQLFLNQ..SFSYHRNSAIKAG..VSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNP.sRAEIEMCREKVYACLDEHCRLEHP.dGRFAQLLLRLPALRSISLKCQDHLF.sDRPLEELF.                             
HN4A_MOUSE         adSSLPSINALLQAEVLSQQIT.kKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
HN4A_RAT           adSSLPSINALLQAEVLSQQIT.kKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
Q9JJI9             adSSLPSINALLQAEVLSQQIT.kKIANIADVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
HN4A_HUMAN         adSSLPSINALLQAEVLSRQIT.kKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                            
HN4A_XENLA         adSSLPSINVLIQAEVLSQQIT.kKIACIIDVCDSMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDILLLGN..DRLIPRNCPELEV...GRVAVRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPTKIKRMRYQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                               
HN4G_MOUSE         ngSNIPSINTLAQAEVRSCQIS.kKIASISDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDILLLGN..HYVIHRNSCEVEV...SRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDP.dPVKIKNMRFQVQISLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
HN4G_HUMAN         ngSNIPSINTLAQAEVRSRQIS.kKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDILLLGN..NYVIHRNSCEVEI...SRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDP.dPVKIKNMRFQVQIGLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
HN4B_XENLA         tdNGSLSINVLTQAEAMVHQYS.kKVASISDVCESMKQQLLLLVEWAKYIPAFCELPLDDQVALLRAHAGAHLLLGVAKRSL.kDFLLLGN..DFIMPMHCPELEI...ARVPCRILDELVKPLREIQIDDNEYVCLKAIIFFDP.dQTKVKNMRFQVQVNLEDYINDRQF.rGRFSDILLLLPPLQSITWQMIEQVQ.iDSLLQELLL                                                                                                     
HNF4_DROME         apGNGLSVISLVKAENESRQSK.kQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSM.kDVLLLSN..NCVITRHCPDPLV.dISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDP.ePHRIKSLRHQILNNLEDYISDRQY.rGRFGEILLILPVLQSITWQMIEQIQ.iDSLLQEMLL                                                                                                     
O97120             sdLPNLTLRCLLSAELSMDPKL.tGLHPLTIICQSIEQQLPRIVNWARQLPVFSslSFDDQFCLIKAAWPELVLISSAYHST.rDGLLLSI..GRHLGREVAKSHG..LGPLVDRILHELVARFRDLSLQRTELALLRAIILFNP.sRHRVEAVREQLYSALHSYCTTNQP.tSRFTKLLLRLPPLRSIASKCLEHLV.iQEKSFELAT                                                                                                     
O77099             stSNGLSVKFLLLAENRSRHFG.kRFASINDVCDSMKQQLLILVEWAKSIPAFAELQLDDQVALLRAHAGEHLLLGLSRRSM.eEMLLLGN..NCIITKQSPDSKM.dISRIGARIIDELVSAIKDIKLDDSELACIKALVFFDP.qPQKIKALRHQVLNNLEDYVSDKQY.rGRFGEILLLLPVLQSITWQMIQQIE.iDSLLQEMLL                                                                                                     
O46174             sqANGLSVVSLLNAELLSRKVI.rKLAKINDVCDSIKQQLLILVEWAKYIPAFTVLHLDDQVALLRAHAGEHLLLGCARRSL.kDILLLGN..NCIITKHNIDGRM.dISMIGMRVMDEIVKPLREIDIDDTEFACLKAIVFFDP.qPQKIKQLRYQIQINLEDYISDRQY.rGRFGELLLCLPPLQSITWQMIEQIQ.vDSLLQEMLL                                                                                                     
                                   



Profile: hERa (based on 3D structure) Number of sequences aligned: 50



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
ESR1_HUMAN         SLTADQMVSALLDAEPPILYSE.sEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TSSRFRMMNLQGEEFVCLKSIILLNS.eKDHIHRVLDKITDTLIHLMAKAGL.hQRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252


ESR2_BOVIN         ALSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLYDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..DLILDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sGRKLTHLLNAVTDALVWVIAKSGM.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
Q9BDW5             slSPEQLVLTLLEAEPPHVLVS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLYDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLTHLLNAVTDALVWVIARSGI.sVRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR2_HUMAN         slSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLAHLLNAVTDALVWVIAKSGI.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR2_SHEEP         ALSPEQLVLTLLEAEPPHVLMS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLYDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sGRKLTHLLNAVTDALVWVIAKSGM.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR2_RAT           slSPEQLVLTLLEAEPPNVLVS.tEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLTHLLNAVTDALVWVIAKSGI.sVRLANLLMLLSHVRHISNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR2_MACMU         ALSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRL