Structural alignment:
Results till now 
442 structures are aligned (of the 920)

We just added the DAX-1 cluster

Here you can find the alignment of 36 sequences, by using Clustal W and our own alignment.


Please take a look at this three important sites considering the aligment:

1) This site for the last information, how far we are at the moment.
2) Manually adjustments to the alignment can be found here.

3) For a better overview take a look at the complete alignment. Go here.

We have removed all C. elegans sequences, and try to align the 93 left.

Details about the numbering can be found here.

                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
CONSENSUS           AELEELISLLLEAEPETFPAA ADLSLFSSLCELATKQLVHVVEWAKRIPGFRELPLDDQVTLLKAGWMELLILRLAWRSA ADTLLFAA AGLTLNREQLKNAA AFGELFDRIFAELASKLRALQLDDEEFACLKAIILLSA AVEKVEKLQEKLLAALEHYIRKRRA AQRFAKLLLKLPDIRSISAKHAEHLA APPLLLEML  
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252


Profile: hRXRa (based on 3D structure) Number of sequences aligned: 69



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
RXRA_HUMAN         SANEDMPVERILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPAEVEALREKVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252

RXRA_MOUSE         SANEDMPVEKILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPAEVEALREKVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRA_RAT           SANEDMPVEKILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPAEVEALREKVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRA_XENLA         SANEDMPVEKILEAEHAVEPKT.sPSDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPLEVEALREKVYASLEAYCKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q90418             AANEEMPVEKILEAEMAVEQKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSELSLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG.eVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIILFNP.sPSEVELLREKVYASLEAYCKQRYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q90415             CANEDMPVEKILEAELAVEPKT.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHTAG..VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPSEVEALRERVYASLEAYCKHKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRB_HUMAN         saPEEMPVDRILEAELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPSEVEVLREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRB_MOUSE         saPEEMPVDRILEAELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGEVEILREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRB_RAT           GAPEEMPVDRILEAELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGEVEILREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q91840             AINEEMPVEKILEAELAVEQKS.sPSDPVTNICQAADKQLFTLVEWAKRIPHFSELALDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGDVEVLREKVYASLESYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRA_BRARE         SFNEEMPVEKILDAELAVEPKT.sTNDPVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSV.kDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNP.nPSEVEALREKVYASLEGYTKHNYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRG_CHICK         GGSEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP.sPSEVESLREKVYATLEAYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRG_HUMAN         SGHEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP.nPSEVETLREKVYATLEAYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q91613             AINEEMPVEKILEAELAVEQKS.sPSDPVTNICQDADKQLFTLVEWAKRIPHfpELPLDDQVILLRAGWNELLIASFSHRSI.kDGILLAT..GLHVHRNSAHSAG..VGAIFERVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPGDVEVLREKVYACLESYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
RXRG_MOUSE         SSHEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNP.nPSEVETLREKVYATLEAYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDSFLMEML.                                                                                                     
RXRG_XENLA         atSEEMPVERILEAELAVDPKI.sTNDPVTNICHAADKQLFTLVEWAKRIPYFSDLPLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHNAG..VGSIFDRVLTELVSKMKDMDMDKSELGCLRAIVLFNP.nAAEVEALREKVYATLESYTKQKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q90417             SANEEMPVEKILEAETAVEHRT.sPNDPVTNICQAADKQLFTLVEWAKRVPHFSDVPLDDQVILLRAGWNELLIAAFSHRSI.kDEILLAT..GLHVPKESTHNLG.eVGALFDRVLTELVCKMRDMQMDKTELGCLRAIVLFNP.sSSEVELLREKVYASLESYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q9UAF1             spNDDMPVDKILEAELISDPKV.nENDPVSNICKAADRQLVTLVEWAKRIPHFSSLPLEDQVILLRAGWNELLIASFSHRSI.kDSILLAS..GLHVHRHSAHQAG..VGPIFDRVLTELVSKMRDMMMDKTELGCLRAIVLFNP.dSAHIESLREKVYASLEAYCRSKYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDKFLMNML.                                                                                                     
Q06310             .............AELAVEQKS.sPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSI.rDGILLAT..GLHVHRNSAHSAG.iFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNP.nPSEVEVLREKVYASLETYCKQKYP.qGRFAKLLLRLPALRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
Q64116             sgHEDMPVERILEAELAVEPKT.sTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSV.qDGILLAT..GLHVHRSSAHSAG..VGSIFDRVLTELVSKMKDMRMDKSELGCLRAIVLFNP.nPSEVETLREKVYATL...............................................                                                                                                     
Q9NG48             SLHSDMPIERILEAEKRVECKM.nYENAVSHICNATNKQLFQLVAWAKHIPHFTSLPLEDQVLLLRAGWNELLIASFSHRSI.kDGIVLAT..GITVHRNSAQQAG..VGTIFDRVLSELVSKMREMKMDRTELGCLRSIILFNP.sIQEVTLLREKIYGALEGYCRVAWP.aGRFAKLLLRLPAIRSIGLKCLEYLF.iDDFLVEML.                                                                                                     
Q9U7D9             SLHTDMPVERILEAEKRVECKA.............ENQVEYELVEWAKHIPHFTSLPLEDQVLLLRAGWNELLIAAFSHRSV.kDGIVLAT..GLTVHRNSAHQAG..VGTIFDRVLTELVAKMREMKMDKTELGCLRSVILFNP.sAQEVELLREKVYAALEEYTRTTHP.pGRFAKLLLRLPSLRSIGLKCLEHLF.iDTFLMEML.                                                                                                     
O61448             aaPPEMPLERILEAELRVESQT.qQQDPVSSICQAADRQLHQLVQWAKHIPHFEELPLEDRMVLLKAGWNELLIAAFSHRSV.rDGIVLAT..GLVVQRHSAHGAG..VGAIFDRVLTELVAKMREMKMDRTELGCLLAVVLFNP.rTCPSGGPEGESVSALEEHCRQQYP.pGRFAKLLLRLPALRSIGLKCLEHLF.iDNFLLSML.                                                                                                     
O61449             agSPDMPLERILEAEMRVEQPA.aSGRDPVNSMCQAAPPLHELVQWARRIPHFEELPIEDRTALLKAGWNELLIAAFSHRSV.rDGIVLAT..GLVVQRHSAHGAG..VGDIFDRVLAELVAKMRDMKMDKTELGCLRAVVLFNP.nATRVEALREKVYAALEEHCRRHHP.pGRFGKLLLRLPALRSIGLKCLEHLF.iDSFLLNML.                                                                                                     
Q9NFY1             NMQAEMPLDRIIEAEKRIECTP.eQHDGVNNICQATNKQLFQLVQWAKLIPHFTSLPMSDQVLLLRAGWNELLIAAFSHRSI.qDAIVLAT..GLTVNKTSAHAVG..VGNIYDRVLSELVNKMKEMKMDKTELGCLRAIILYNP.sVQEVEMLREKIYGVLEEYTRTTHP.pGRFAKLLLRLPALRSIGLKCSEHLF.iDTFLMEML.                         
O76241             saISDMPIASIREAELSVDPID.pLQDVVSNICQAADRHLVQLVEWAKHIPHFTDLPIEDQVVLLKAGWNELLIASFSHRSM.eDGIVLAT..GLVIHRSSAHQAG..VGAIFDRVLSELVAKMKEMKIDKTELGCLRSIVLFNP.cVNDVEILREKVYAALEEYTRTTYP.pGRFAKLLLRLPALRSIGLKCLEYLF.lDSYLMKMLV                                                                                                          
O45117             GPGRDITVERLMEADQMSEARC.eYRAPVSAICAMVNKQVFQHMDFCRRLPHFTKLPLNDQMYLLKQSLNELLILNIAYMSI.aDGSLERR.rNYTLGRNMAVQAG..VVQIFDRILSELSVKMKRLDLDATELCLLKSIVVFNP.dRKSIDLLRSRIYASLDEYCRQKHP.dGRFAQLLLRLPALRSISLKCLDHLF.vENSVIEEFH                             
O96562             adLPMIPIESIIAAETLVDPGI.aNTDPIRHVCLAADKQLASLAEWAKRLPHFRDLSIADQVVLLQWSWPELLIGGFCHRSC.kDGILLST..GLHLTRDNLKKAG..VGAIIDKIFSEVIEKMQEIQMDRAEWGCLRAIMLFSP.aIDQVENYRELYTSTLEDHVKRKHP.pDRFTKVILRIPALKSIGLQALEHLY.mDTFLLDML.                                                                     
Q91430             asYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_MOUSE         asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_BOVIN         asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_CHICK         asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_RAT           asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT2_HUMAN         asYLSGYISLLLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT1_BOVIN         acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT1_HUMAN         acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
COT1_MOUSE         acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
Q9W745             acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCIKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
Q9PS79             asYLSGYISLVLRAEPYPTSRF.nNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSM.vAPLSAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dVAHVESLQEKSQCALEEYVRSQYP.pTRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
SV44_BRARE         acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCIKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
Q62681             acYLSGYISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSM.vA.VLAA..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS.dAAHIESLQEKSQCALEEYVRSQYP.pSRFGKLLLRLPSLRTVSSSVIEQLF.iETLIRDMLL                                                                                                     
Q9BMU6             gsYLSSYISLLLRAEPYPTSRY.nNIMGIDNICELAARLLFSAVEWARNIPFFPDLQVTDQVALLRLVWSELFVLNASQCSM.vAPLLAA..AGLHASPMAADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT.dVAHIESLQEKSQCALEEYCRSQYP.pTRFGKLLLRLPSLRTVSSQVIEQFF.iETLIRDMLL                                                                                                     
7UP1_DROME         csYLSSYISLLLRAEPYPTSRY.nNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSM.vAPLLAA..AGLHASPMAADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT.dVTHIESLQEKSQCALEEYCRTQYP.pTRFGKLLLRLPSLRTVSSQVIEQLF.iETLIRDMLL                                                                                                     
SV46_BRARE         apYLSGFISLLLRAEPYPTSRY.nNLMGIENICELAARLLFSAVEWAKNIPFFPDLQLMDQVALLRMSWSELFVLNAAQCSM.vAPLLAA..AGLHASPMSAERVV..AFMDHIRVFQEQVEKLKALQVDTAEYSCLKSIVLFTS.dVAHVESIQEKSQCALEEYVRNQYP.pNRFGRLLLRLPSLRIVSSPVIEQLF.iETLLRDMLL                                                                                                     
Q91720             asYLTGFISLLLRAEPYPTSRY.nNIMGIENICELAARLLFSAIEWAKNIPFFPDFQLSDQVSLLRMTWSELFVLNAAQCSM.vAPLLAR..AGLHASPMSADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIALFTP.dIGHVESIQEKSQCALEEYVRNQYP.pTRFGRLLLRLPSLRIVSAPVIEQLF.iETLIRDMLL                                                                                        
7UP2_DROME         csYLSSYISLLLRAEPYPTSRY.nNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSM.vAPLLAA..AGLHASPMAADRVV..AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTT................................................................                                                                                 
Q9BUE8             aqPVSELIAQLLRAEPYPAAAG.gAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAAL.tAPLLAA..AGLHAAPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISQLF.iETLIRDMLL                                                                                                     
EAR2_HUMAN         aqPVSELIAQLLRAEPYPAAAG.gAVLGIDNVCELAARLLFSTVEWARH.GFFPELPVADQVALLRMSWSELFVLNAAQAAL.tAPLLAA..AGLHAAPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISQLF.iETLIRDMLL                                                                                                     
EAR2_MOUSE         apPVSELIAQLLRAEPYPAAGR.gAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVALLRLSWSELFVLNAAQAAL.tAPLLAA..AGLHAAPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISKLF.iETLIRDMLL                                                                                                     
EAR2_RAT           apPVSELIAQLLRAEPYPAAGR.gAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVGLLRLSWSELFVLNAAQAPV.tAPLLAA..AGLHAGPMAAERAV..AFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTP.dPAHVESLQEKAQVALTEYVRAQYP.pQRFGRLLLRLPALRAVPASLISQLF.iETLIRDMLL                                                                                          
Q9GSG7             SSVRDVTIERIHEAEQLSEQKS.eYKGAVSHLCQMVNKQIYQLIDFARRVPHFINLPRDDQVMLLRCGWNEMLIAAVAWRSM.qLMCLGP...NFTLHRNSAQQAG..VDTLFDRILCELGIKMKRLDVTRAELGVLKAIILFNP.cQKEIDGMREKIYACLDEHCKQQHP.dGRFAQLLLRLPALRSISLKCLDHLN.lDSFIVEML.                                                                                                     
Q9GSG8             SSVRDVTIERIHEAEQLSEQKS.eYKGAVSHLCQMVNKQIYQLIDFARRVPHFINLPRDDQVMLLRCGWNEMLIAAVAWRSM.qLMCLGP...NFTLHRNSAQQAG..VDTLFDRILCELGIKMKRLDVTRAELGVLKAIILFNP.cQKEIDGMREKIYACLDEHCKQQHP.dGRFAQLLLRLPALRSISLKCLDHLN.lDSFIVEML.                                                                                                     
Q9U3Y3             SSVRDVTIERITAAEQLSEQKS.eYKGAVSHLCQMVNKQIYQLIDFARRLPHFTNLHRDDQVMLLRCGWNEMLIAAVAWRSM.qLMCLGP...NFTLHRNSAQQAG..VDTLFDRILCELGIKMKRLDVTRAELGVLKAIILFNP.cQNGDDGMREKIYACLDEHCKQQHP.dGRFAQLLLRLPALRSISLKCLDHLN.lDNFIIEML.                                                                                                     
USP_CHOFU          svSDELSIERLTEMESLVADPS.rYRAPVSSLCQIGNKQIAALVVWARDIPHFGQLELDDQVVLIKASWNELLLFAIAWRSM.qLMCLMP...GMTLHRNSAQQAG..VGAIFDRVLSELSLKMRTLRMDQAEYVALKAIVLLNP.nRQEVDVLREKMFSCLDDYCRRSRS.eGRFASLLLRLPALRSISLKSFEHLY.iSGYIREAL. 
USP_MANSE          SSVQELSIERLLEIESLVADPP.kYRAPVSSLCQIGNKQIAALVVWARDIPHFGQLELEDQILLIKNSWNELLLFAIAWRSM.qLMCLMP...GMTLHRNSALQAG..VGQIFDRVLSELSLKMRTLRMDQAEYVALKAIILLNP.nKPEVVVLREKMFSCLDEYVRRSRC.eGRFAALLLRLPALRSISLKCFEHLY.iASYIHDAL.                                                                                                     
USP_BOMMO          SSVQELSIERLLELEALVADSA.kYRAPVSSLCQIGNKQIAALIVWARDIPHFGQLEIDDQILLIKGSWNELLLFAIAWRSM.qLICLMP...GMTLHRNSALQAG..VGQIFDRVLSELSLKMRSLRMDQAECVALKAIILLNP.nKQEVDVLREKMFLCLDEYCRRSRG.eGRFAALLLRLPALRSISLKSFEHLY.vSSYIRDAL.                                                                                                                                             
USP_DROME          SVSRDFSIERIIEAEQRAETQC.dYKGAVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSI.pQQLFLNQ..SFSYHRNSAIKAG..VSAIFDRILSELSVKMKRLNLDRRELSCLKAIILYNP.sRAEIEMCREKVYACLDEHCRLEHP.dGRFAQLLLRLPALRSISLKCQDHLF.sDRPLEELF.                             
HN4A_MOUSE         adSSLPSINALLQAEVLSQQIT.kKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
HN4A_RAT           adSSLPSINALLQAEVLSQQIT.kKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
Q9JJI9             adSSLPSINALLQAEVLSQQIT.kKIANIADVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
HN4A_HUMAN         adSSLPSINALLQAEVLSRQIT.kKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDVLLLGN..DYIVPRHCPELAE..MSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDP.dPGKIKRLRSQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                            
HN4A_XENLA         adSSLPSINVLIQAEVLSQQIT.kKIACIIDVCDSMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDILLLGN..DRLIPRNCPELEV...GRVAVRILDELVLPFQELQIDDNEYACLKAIIFFDP.dPTKIKRMRYQVQVSLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                               
HN4G_MOUSE         ngSNIPSINTLAQAEVRSCQIS.kKIASISDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDILLLGN..HYVIHRNSCEVEV...SRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDP.dPVKIKNMRFQVQISLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
HN4G_HUMAN         ngSNIPSINTLAQAEVRSRQIS.kKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSM.kDILLLGN..NYVIHRNSCEVEI...SRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDP.dPVKIKNMRFQVQIGLEDYINDRQY.rGRFGELLLLLPTLQSITWQMIEQIQ.iDNLLQEMLL                                                                                                     
HN4B_XENLA         tdNGSLSINVLTQAEAMVHQYS.kKVASISDVCESMKQQLLLLVEWAKYIPAFCELPLDDQVALLRAHAGAHLLLGVAKRSL.kDFLLLGN..DFIMPMHCPELEI...ARVPCRILDELVKPLREIQIDDNEYVCLKAIIFFDP.dQTKVKNMRFQVQVNLEDYINDRQF.rGRFSDILLLLPPLQSITWQMIEQVQ.iDSLLQELLL                                                                                                     
HNF4_DROME         apGNGLSVISLVKAENESRQSK.kQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSM.kDVLLLSN..NCVITRHCPDPLV.dISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDP.ePHRIKSLRHQILNNLEDYISDRQY.rGRFGEILLILPVLQSITWQMIEQIQ.iDSLLQEMLL                                                                                                     
O97120             sdLPNLTLRCLLSAELSMDPKL.tGLHPLTIICQSIEQQLPRIVNWARQLPVFSslSFDDQFCLIKAAWPELVLISSAYHST.rDGLLLSI..GRHLGREVAKSHG..LGPLVDRILHELVARFRDLSLQRTELALLRAIILFNP.sRHRVEAVREQLYSALHSYCTTNQP.tSRFTKLLLRLPPLRSIASKCLEHLV.iQEKSFELAT                                                                                                     
O77099             stSNGLSVKFLLLAENRSRHFG.kRFASINDVCDSMKQQLLILVEWAKSIPAFAELQLDDQVALLRAHAGEHLLLGLSRRSM.eEMLLLGN..NCIITKQSPDSKM.dISRIGARIIDELVSAIKDIKLDDSELACIKALVFFDP.qPQKIKALRHQVLNNLEDYVSDKQY.rGRFGEILLLLPVLQSITWQMIQQIE.iDSLLQEMLL                                                                                                     
O46174             sqANGLSVVSLLNAELLSRKVI.rKLAKINDVCDSIKQQLLILVEWAKYIPAFTVLHLDDQVALLRAHAGEHLLLGCARRSL.kDILLLGN..NCIITKHNIDGRM.dISMIGMRVMDEIVKPLREIDIDDTEFACLKAIVFFDP.qPQKIKQLRYQIQINLEDYISDRQY.rGRFGELLLCLPPLQSITWQMIEQIQ.vDSLLQEMLL                                                                                                     
                                   



Profile: hERa (based on 3D structure) Number of sequences aligned: 50



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
ESR1_HUMAN         SLTADQMVSALLDAEPPILYSE.sEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TSSRFRMMNLQGEEFVCLKSIILLNS.eKDHIHRVLDKITDTLIHLMAKAGL.hQRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252


ESR2_BOVIN         ALSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLYDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..DLILDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sGRKLTHLLNAVTDALVWVIAKSGM.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
Q9BDW5             slSPEQLVLTLLEAEPPHVLVS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLYDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLTHLLNAVTDALVWVIARSGI.sVRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR2_HUMAN         slSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLAHLLNAVTDALVWVIAKSGI.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR2_SHEEP         ALSPEQLVLTLLEAEPPHVLMS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLYDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sGRKLTHLLNAVTDALVWVIAKSGM.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR2_RAT           slSPEQLVLTLLEAEPPNVLVS.tEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLTHLLNAVTDALVWVIAKSGI.sVRLANLLMLLSHVRHISNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR2_MACMU         ALSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.TTSRFRELKLQHKEYLCVKAMILLNS.sSRKLAHLLNAVTDALVWVIAKSGI.sMRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR1_CHICK         SLTAEQMVSALLEAEPPIVYSE.nEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TAARFRMMNLQGEEFVCLKSIILLNS.eRDYIHRVLDKITDTLIHLMAKSGL.hRRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_POEGU         SLTAEQMVSALLEAEPPLVYSE.nEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TAARFRMMNLQGEEFVCLKSIILLNS.eKDYIHRVLDKITDTLIHLMAKSGL.hRRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.                                        
ESR2_MOUSE         SLSPEQLVLTLLEAEPPNVLVS.tEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFGMLLA.TTARFRELKLQHKEYLCVKAMILLNS.sSRKLTHLLNAVTDALVWVISKSGI.sVRLANLLMLLSHVRHISNKGMEHLL.vYDLLLEMLN
ESR1_MICUN         tmSPDQVLLLLQGAEPPVLCSR.tEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRSEGDCVE.GMAEIFDMLLA.TTSRFRMLKLKTEEFVCLKAIILLNS.dGAAVQNMLDTITDALIHHISQSGC.sRRQAHLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_PAGMA         SMPPDQVLLLLQGAEPPMLCSR.tEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRSEGDCVE.GMAEIFDMLLA.TASRFRMLKLKPEEFVCLKAIILLNS.dGAAVQNMLDTITDALIHHINQSGC.sRRQAQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_PIG           SLTADQMISALLEAEPPIIYSE.sEASMMGLLTNLADRELVHMINWAKRVPGFLDLSLHDQVHLLECAWLEILMIGLVWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TSSRFRMMNLQGEEFVCLKSIILLNS.eKDHIHRVLDKITDTLIHLMAKAGL.hRRLAQLLLILSHFRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_HORSE         SLTAEQMISALLDAEPPVLYSE.nEASMMGLLTNLADRELVHMINWAKRVPGFVDLSLHDQVHLLECAWLEILMIGLVWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TSSRLRMMNLQGEEFVCLKSIILLNS.eKDHIHRVLDKMTDTLIHLMAKAGL.hRRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR2_CALJA         slSPEQLVLTLLEAEPPHVLIS.tEASMMMSLTKLADEELVHMISWAKKIPGFVELSLLDQVRLLESCWLEVLMVGLMWRSI.pGKLIFAP..NLILDRDEGKCVE.GILEVFDMLLA.TTSRFRELKLQHKEYLCVKAMVLLNS.sSQKLAHLLNAVTDALVWVIAKSGF.sVRLANLLMLLSHIRHASNKGMEHLL.vYDLLLEMMN                                                                                                     
ESR1_MOUSE         SLTADQMVSALLDAEPPMIYSE.sEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TSSRFRMMNLQGEEFVCLKSIILLNS.eKDHIHRVLDKITDTLIHLMAKAGL.hRRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_SPAAU         SMPPDQVLLLLRGAEPPMLCSR.tEVTVMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRSEGDCVE.GMAEIFDMLLA.TASRFRMLKLKPEEFVCLKAIILLNS.dSAAVQNMLDTITDALIHHINQSGC.sRRQAQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR2_COTJA         avSPEQFVLTLLEAEPPNVLVS.tEASMMMSLTKLADKELVHMIGWAKKIPGFIDLSLYDQVRLLESCWLEVLMIGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.MTSRFRELKLQHKEYLCVKAMILLNS.sNRKLHHLLNVVTDALVWVIAKSGI.tTRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR2_CHICK         avSPEQFVLTLLEAEPPNVLVS.tEASMMMSLTKLADKELVHMIGWAKKIPGFIDLSLYDQVRLLESCWMEVLMIGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.MTSRFRELKLQHKEYLCVKAMILLNS.sNRKLHHLLNVVTDALVWVIAKSGI.tTRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR1_RAT           SLTADQMVSALLDAEPPLIYSE.sEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TTSRFRMMNLQGEEFVCLKSIILLNS.eKDHIHRVLDKINDTLIHLMAKAGL.hRRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR2_STUVU         svSPEQFVLTLLEAEPPHVLVS.tEASMMMSLTKLADKELVHMIGWAKKIPGFIDLSLYDQVRLLESCWMEVLMIGLMWRSI.pGKLIFAP..DLVLDRDEGKCVE.GILEIFDMLLA.MTSRFRELKLQHKEYLCVKAMILLNS.sNRKLHHLLNVVTEALVWVIAKSGI.tTRLANLLMLLSHVRHASNKGMEHLL.vYDLLLEMLN                                                                                                     
ESR1_ONCMY         TMPPEQVLFLLQGAEPPALCSR.tEVTMMTLLTSMADKELVHMIAWAKKVPGFQELSLHDQVQLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRSEGDCVE.GMAEIFDMLLA.TVSRFRMLKLKPEEFVCLKAIILLNS.nSSAVESMLDNITDALIHHISHSGA.pRRQAQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_SALSA         smPPEQVLFLLQGAEPPALCSR.tEVTMMTLLTSMADKELVHMIAWAKKVPGFQELSLHDQVQLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRSEGDCVE.GMAEIFDMLLA.TVSRFRMLKLKPEEFVCLKAIILLNS.nSSAVESMLDNITDALIHHISHSGA.pRRQVQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
Q98SM9             smSPDQVLLLLLGAEPPAVCSR.tEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRSEGECVE.GMAEIFDMLLA.TVARFRSLKLKLEEFVCLKAIILINS.dNFMVQCMLDNITDALIYCISKSGA.sRRQAQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_ORENI         smPPDQVLLLLQGAEPPILSSR.tEVTIMTLLTSMADKELVHMITWAKKLPGFLQLSLHDQVLLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRNEGTCVE.GMAEIFDMLLA.TASRFRVLKLKPEEFVCLKAIILLNS.dSAAVQHMLDTITDALIFHISHLGC.sRRQAQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_BRARE         smPPDQVLLLLLGAEPPAVCSR.tEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRSEGECVE.GMAEIFDMLLA.TVARFRSLKLKLEEFVCLKAIILINS.dNFMVQCMLDNITDALIYCISKSGA.sRRQAQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_MESAU         SLTADQMVSALLDAEPPLIYSE.sEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLIWRSM.pGKLLFAP..NLLLDRNQGKCVE.GMVEIFDMLLA.TSARFRMMDLQGEEFVCLKSIILLNS.eKDHIHRVLDKITDTLIHLMAKAGL.hRRLAQLLLILSHIRHMSNKGMEHLY.fYDLLLEML.                                                                                                     
ERB2_CARAU         slSPEQLVNCILEAEPPQIYLR.tEASMMMSLTNLADKELVLMISWAKKIPGFVELTLSDQVHLLECCWLDILMLGLMWRSV.pGKLIFSP..DLKLNRDEGTCVE.GIMEIFDMLLA.TTSRFRELKLQREEYVCLKAMILLNS.sRGKVLRLLDSVTDALVWTISRTGL.sIRLAHLLMLLSHIRHLSNKGIEHLS.lYDLLLEML.                                                                                                     
ESR1_ORYLA         SIPPEQVLLLLQGAEPPILCSR.tEVTMMTLLTSMADKELVHMIAWAKKLPGFLQLSLHDQVLLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRNEGDCVE.GMTEIFDMLLA.TASRFRVLKLKPEEFVCLKAIILLNS.nSAAVQSMLDTITDALIHYISQSGY.aRRQAQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
Q98SM7             SLSPEELISRIMEAEPPEIYLM.tEANVMMSLTNLADKELVHMISWAKKIPGFVELSLFDQVHLLECCWLEVLMLGLMWRSV.pGKLIFSP..DLCLSRDESSCVQ.GLVEIFDMLLA.ATSRFRELKLQREEYVCLKAMILLNS.sRSKLLCVLDSVTDALVWAISKTGL.sTRLAHLLMLLSHIRHVSNKGMDHQH.lYDLLLEML.                                                                                                     
Q9DDJ3             SMPPDQVLLLLQGAETPILYSR.tEVTMMTLLTSMADRELVHMIAWAKKLPGFLQLTHHDQVQLLESSWLEVLMIGLIWRSI.rGKHIFAQ..DLILDRNEGDCVE.GMAEIFDMLLA.TTSPFRMLKLKPEEFVCLKAIVLLNS.dSAPVQDMLDIITDALIHHISQSGC.sRRQAQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR1_ANOCA         SLTADQMVSALLEAEPPVVYSE.nEASVMTLLTNLADRELVHMINWAKRVPGFVDLALHDQVHLLECAWLEILMVGLVWRSM.pGKLLFAP..NLLLDRSHGKVVE.GFVEIFDMLLA.ASSRFRMMNVRGEEFVCLKSIILLNP.eRDHIHRVLDKITDTLMHLMAKSGL.hRRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR2_ONCMY         slTPEELIARIMDAEPPEIYLM.tEANVMMSLTNLADKELVHMISWAKKVPGFVELSLFDQVHLLECCWLEVLMLGLMWRSV.pGKLIFSP..DLSLSRDEGSCVQ.GFVEIFDMLLA.ATSRFRELKLQREEYVCLKAMILLNS.rRSKLLCLLDSVTDALVWAISKTGL.sTRLAHLLMLLSHIRHLSNKGMDHLH.lYDLLLEML.                                                                                                     
ESR1_ICTPU         smSPEQVLLLLLRAEPPTLCSR.sELTIMSLLTNMADRELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEILMIGLIWRSI.pGKLIFAQ..DLILDKSEGECVE.GMAEIFDMLLA.TVARFRTLKLKSEEFVCLKAIILLNS.dGFMVQCMMDNITDALIYYISQSGI.sRRQAQLLLLLSHIRHMSYKGMEHLY.lYDLLLEML.                                                                                                     
ESR2_ANGJA         ALTPEQLINRIIEAEPPEIYLM.tEDSMMMSLTNLADKELVLMISWAKKIPGFVELDLSDQVHLLECCWLEVLMLGLMWRSV.pGKLIFSP..DLKLNRDEGSCVE.GILEIFDMVLA.ATSRFRELKLQREEYVCLKAIILLNP.sRNKLLHMLDSVTDALVWTIAKKGL.sARLAHLLMLLAHIRHLSNKGMEHLS.lYDLLLEML.                                                                                                     
ESR2_ORENI         ALTPEQLIERILEAEPPEIYLV.tEASVMMLLTNLADKELVHMISWAKKIPGFVELSLVDQVHLLECCWLEVLMIGLMWRSV.pGKLIFCP..DLSLSREEGSCVQ.GFVEIFDMLIA.ATTRVRELKLQREEYVCLKAMILLNS.sRSKLLRLLDAMTDALVLAIGKTGL.yTRLAHLLMLLSHIRHVSNKGMDHLH.lYDLLLEML.                                                                                                     
Q98SM8             aySPEQLVSCILEAEPPQIYLR.tEASMMMSLTSLADKEPVLMISWAKKIPGFVELTLSDQVHLLECCWLDILMLGLMWRSV.pGKLIFTP..DLKLNREEGNCVE.GIMEIFDMLLA.TTSRFRELKLQREEYVCLKAMILLNS.sRGKVLNLLDSVTDALVWIISRTGL.sIRLAHLLMLLSHIRHLSNKGIEHLS.lYDLLLEML.                                                                                                     
ESR2_ICTPU         slSPEQLVYCILEAEPPQIYLK.tESTVMMSLTQLADKELVLMISWAKKIPGFVELSLAHQVQLLECCWLEVLMLGLMWRSI.pGKLIFSL..DLKLNRDEGNCVE.GIMEIFDMLLA.GSSRFRELKLQKEEYVCLKALILLNS.sRTKLLRLLDAVTDALVWAISRTGL.sARLAHLLMLLSHIRHLSNKGMEHLS.lYDLLLEML.                                                                                                     
ESR1_OREAU         smPPDQVLLLLQGAEPPILCSR.tEVTIMTLLTSMADKELVHMITWAKKLPGFLQLSLHDQVLLLESSWLEVLMIGLIWRSI.pGKLIFEE..DLILDRNEGTCVE.GMAEIFDMLLA.TV.RFRVLKLKPEEFVCLKAIILLNS.dSVAVQHMLDTITDALIFHISHFGC.sRRQAQLLLLLSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ERB1_CARAU         ALSPEELIARIMDAEPPEIYLM.tEANVMMSLTNLADKELVHMISWAKKIPGFVEIGLFDQVHLLECCWLEVLMLGLMWRSV.pGKLVFSP..DLSLSRDEGSCVQ.GFAEIFDMLLA.ATSRFRELKLQREEYACLKAMILLNS.sRSKLLCLLDSVTDALVWAISKTGL.sTRLAHLLMLLSHIRHVSNKGMDHLH.lYDLLLEML.                                                                                                     
ESR2_SPAAU         ALTSKQLIERIMEAEPPEIYLM.tEANIMMSLTNLADKELVHMITWAKKIPGFLELGLLDQVHLLECCWLEVLMIGLMWRSV.pGKLIFSP..DLSLSREEGSCVQ.GFLEIFDMLIA.ATSRVRELKLQREEYVCLKAMILLNS.sRSKLLRLLDAVTDALVWAIAKTGL.yTRLAHLLMLLSHIRHVSNKGMDHLH.lYDLLLEML.                                                                                                     
ESR3_MICUN         ALTSEQLIERLMEAEPPEIYLM.tEAKVMMSLTNLADKELVHMITWAKKIPGFVELGLLDQVHLLECCWLEVLMVGLMWRSV.pGKLVFSP..DLSLSREEGSCVQ.GFAEIFDMLLA.ATSRVRELKLQREEYVCLKAMILLNS.sSSKLLRLLDAVTDALVSAIGKTVL.yTRLAHLLMLLSHIRHVSNKGMDHLH.lYDLLLEML.                                                                                                     
ESR1_XENLA         SLTAEQLISALMEAEAPIVYSE.sEASMMTLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMVGLIWRSV.pGKLSFAP..NLLLDRNQGRCVE.GLVEIFDMLVT.TATRFRMMRLRGEEFICLKSIILLNS.dTDLIHIILDKIIDTLVHFMAKSGL.qRRLAQLLLILSHIRHMSNKGMEHLY.lYDLLLEML.                                                                                                     
ESR2_MICUN         AMSPEEFISRIMDAEPPEIYLM.tEASMMMSLTNLADKELVFMISWAKKIPGFVELSLADQINLLKCCWLEILMLGLMWRSV.pGKLIFSP..DFKLNREEGQCVE.GIMEIFDMLLA.GTSRFRELKLQREEYVCLKAMILLNS.sRNKLLRLLDSVIDALVWAISKMGL.tLRLGHLTMLLSHIRHVSNKGMDHLS.vYDLLLEML.                                                                                                     
ESR1_CNEUN         SLTADQIVSALLEAEPPVVYSE.sEASMMTLLTNLADRELVHMINWAKRVPGFVDLSLHDQVHLLECAWLEILMIGLVWRSV.pGKLLFAP..NLLLDRNQGKCVE.GFVEIFDMLLA.TSSRFRMMNVQGEEFVCLKSIILLNS.eKDHIHRVLDKIIDTLLHLMAKSGL.hRRLAQLLLILSHFRHMSNKGM...............                                                                                                     
Q9I984             CMSPDQVLLLLLGAEPPAVCSR.tEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRSEGECVE.GMAEIFDMLLA.TVARFRSLKLKLEEFVCLKAIILINS.dNFMVQCMLDNITDALIYCISKSGA.sRRQAQLLLLLSHIRHMSNKGM...............                                                                                                     
Q9DDZ4             smSPDQVLLLLQGAEPPMLCSR.lTSMADKELVHMADKELVHMITWAKKLPGFLQLSLHDQVQLLESSWLEVLMIGLIWRSI.pGKLIFAQ..DLILDRNEGDCVE.GFVEIFDMLLA.TASRFRMLKLKPEEFVCLKAIILLNS.nSVEVHNMLDTITDALIHHISQSGC.sRRQAQLLLLLSHIRH.....................                                                                                                     
ERR2_RAT           skPLTKIVSYLLVAEPDKLYAM.gDIKALTTLCDLADRELVFLISWAKHIPGFSNLTLGDQMSLLQSAWMEILILGIVYRSL.dDKLAYAE..DYIMDEEHSRLV..GLLELYRAILQ.LVRRYKKLKVEKEEFVMLKALALANS.nLEAVQKLQDLLHEALQDYELSQRH.pRRAGKLLLTLPLLRQTAAKAVQHFY.mHKLFLEML.                                                                                                     
ERR3_HUMAN         skPYNKIVSHLLVAEPEKIYAM.sDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSL.eDELVYAD..DYIMDEDQSKLA..GLLDLNNAILQ.LVKKYKSMKLEKEEFVTLKAIALANS.dVEAVQKLQDVLHEALQDYEAGQHM.pRRAGKMLMTLPLLRQTSTKAVQHFY.mHKLFLEML.                                                                                                     
ERR2_HUMAN         skPLTKIVSYLLVAEPDKLYAM.gDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSL.dDKLVYAE..DYIMDEEHSRLA..GLLELYRAILQ.LVRRYKKLKVEKEEFVTLKALALANS.dLEAVQKLQDLLHEALQDYELSQRH.pWRTGKLLLTLPLLRQTAAKAVQHFY.mHKLFLEML.                         
ERR2_MOUSE         tkPLTKIVSNLLGVEQDKLYAM.gDIKALTTLCELADRELVFLINWAKHIPGFPSLTLGDQMSLLQSAWMEILILGIVYRSL.dDKLAYAE..DYIMDEEHSRLV..GLLDLYRAILQ.LVRRYKKLKVEKEEFMILKALALANS.nLEAVQKLQDLLHEALQDYELSQRH.pRRAGKLLWTLPLLRQTAAKAVQHFY.mHKLFLEML.                                                                                                     
ERR1_HUMAN         TAPVNALVSHLLVVEPEKLYAM.gHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSL.qDELAFAE..DLVLDEEGARAA..GLGELGAALLQ.LVRRLQALRLEREEYVLLKALALANS.dAEAVEQLREALHEALLEYEAGRAG.rRRAGRLLLTLPLLRQTAGKVLAHFY.mHKLFLEML.                                                                                                     
ERR1_MOUSE         TAPVNALVSHLLVVEPEKLYAM.gHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSL.qDELAFAE..DLVLDEEGARAA..GLGDLGAALLQ.LVRRLQALRLEREEYVLLKALALANS.dAEAVEQLREALHEALLEYEAGRAG.rRRAGRLPCTLPLLRQTAGKVLAHFY.mHKLFLEML.             




Profile: AR (based on 3D structure) Number of sequences aligned: 57



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |                                                              
ANDR_RAT           YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252
                                                                      

ANDR_HUMAN         YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
ANDR_RABIT         YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
ANDR_MACFA         YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
ANDR_CANFA         YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
ANDR_EULFC         YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
ANDR_PANTR         YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
ANDR_PAPHA         YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
Q9GKL7             YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
ANDR_MOUSE         YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
Q9GKN9             YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIVMQEK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
Q9UN21             YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGLRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKAMLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVHPIARELHQFTF.fPEMMAEIIS                                                                                                     
Q13771             YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGLRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKAMLIFFF.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKLLDSVQPIARELHQFTF.fPEMMAEIIS                                                                                                     
Q91445             YECQPIFLNVLEAIEPGVVCAG.sFSNLLTSLNELGERQLVYVVKWAKALPGFRNLHVDDQMSIIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCIRMRH.LSQEFGWLQITPQGFLCMKALLFFSI.nQKLFDELRMNYIKELDRIIACKRK.sRRFYQLTKVLDSVTPIAKDLHQFTF.yPEMMAEIIS                                                                                                     
P70048             YSCQPIFLNVLEAIEPVVVCAG.sFALLLSSLNELGERQLVHVVKWAKALPGFRNLHVSDQMTVIQYSWMGLMIFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRLRH.LSQEFGWLQITPEEFLCMKALLLFSI.dQKCFDELRMNYIKELDRVISCKRN.sRRFFQLTKLLDSVQPIARELHQFTF.yPEMMSEIIS                                                                                                     
O93497             FNSQVVFLNVLESIEPEVVNAG.sAATLLTSLNELGERQLVKVVKWAKGLPGFRNLHVDDQMTVIQHSWMGVMVFGLGWRSY.gRMLYFAP..DLVFNEHRMHIST..MYEHCIRMRH.LSQEFLLLQITQEEFLCMKALLLFSI.sQKYFDELRLTYINELDRLINYRMN.sQRFYQLTRLLDSLQMTVKKLHQFTF.fPEMIGEIIS                                                                                                     
PRGR_RAT           IQLVPPLINLLMSIEPDVVYAG.tSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSY.gQMLYFAP..DLILNEQRMKELS..FYSLCLTMWQ.IPQEFVKLQVTHEEFLCMKVLLLLNT.sQSQFEEMRSSYIRELIKAIGLRQK.sQRFYQLTKLLDSLHDLVKQLHLYCL.fPEMMSEVI.                                                                                                     
PRGR_RABIT         IQLIPPLINLLMSIEPDVIYAG.tSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSY.gQMLYFAP..DLILNEQRMKESS..FYSLCLTMWQ.IPQEFVKLQVSQEEFLCMKVLLLLNT.sQSQFEEMRSSYIRELIKAIGLRQK.sQRFYQLTKLLDNLHDLVKQLHLYCL.fPEMMSEVI.                                                                                                     
PRGR_MOUSE         IQLVPPLINLLMSIEPDVIYAG.tSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSY.gQMLYFAP..DLILNEQRMKELS..FYSLCLTMWQ.IPQEFVKLQVTHEEFLCMKVLLLLNT.sQSQFEEMRSSYIRELIKAIGLRQK.sQRFYQLTKLLDSLHDLVKQLHLYCL.fPEMMSEVI.                                                                                                     
Q9GLW0             IQLIPPLINLLMSIEPDVIYAG.tSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSY.gQMLYFAP..DLILNEQRMKESS..FYSLCLTMWQ.IPQEFVKLQVSQEEFLCMKVLLLLNT.sQNQFEEMRSSYIRELIKAIGLRQK.sQRFYQLTKLLDNLHDLVKQLHLYCL.fPEMMSEVI.                                                                                                     
PRGR_HUMAN         IQLIPPLINLLMSIEPDVIYAG.tSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSY.gQMLYFAP..DLILNEQRMKESS..FYSLCLTMWQ.IPQEFVKLQVSQEEFLCMKVLLLLNT.sQTQFEEMRSSYIRELIKAIGLRQK.sQRFYQLTKLLDNLHDLVKQLHLYCL.fPEMMSEVI.                                                                                                     
O93244             ihSQLVFLNILESIEPEVVHAG.sAAALLTSLNELGERQLVKVVKWAKGLPGFRNLHVDDQMTVIQHSWMGVMVFGLGWRSY.cRLLYFAP..DLVFNDHRMHISS..MFDHCIRMRQ.LSQEFVLLQVTQEEFLCMKALLLFSI.sQKYFDELRLTYINELGRVINYGRK.sQRLYQLTRLMDSLQPVVRKLQQFTF.fPEMIAEIIS                                                                                                     
PRGR_SHEEP         LQLIPPLINLLMSIEPDMVYAG.tSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSY.gQMLYFAP..DLILNEQRMKESS..FYSLCLTMWQ.IPQEFVKLQVSQEEFLCMKVLLLLNT.sQNQFEEMRSSYIRELIKAIGLRQK.sQRFYQLTKLLDNLHDLVKQLHLYCL.fPEMMSEVI.                                                                                                     
O93245             ihSQLVFLNILESIEPEVVNAG.sAAVLLTSLNELGERQLVKVVKWAKGMPGFRNLHVDDQMTVIQHSWMGVMVFGLGWRSY.aRMLYFAP..DLVFNDHRMHISS..MFEHCIRMRH.LSQQFVLLQVTQEEFLCMKALLLFSI.sQKYFDELRLTYINELDRVINYGRK.sQRFYQLTRLMDSLQPIVRKLQQFTF.fPEMIAEIIS                                                                                                     
GCR_SAGOE          PQLTPTLVSLLEVIEPEVLYAG.sTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSY.sNLLCFAP..DLIINEQRMTLPC..MYDQCKHMLY.VSSELHRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHEVVENLLNYCF.fPEMLAEII.                                                                                                     
GCR_SAIBB          PQLTPTLVSLLEVIEPEVLYAG.sTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSY.sNLLCFAP..DLIINEQRMTLPC..MYDQCKHMLY.VSSELHRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHEVVENLLNYCF.fPEMLAEII.                                                                                                     
GCR_SAISC          PQLTPTLVSLLEVIEPEVLYAG.sTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSY.sNLLCFAP..DLIINEQRMTLPC..MYDQCKHMLY.VSSELHRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHEVVENLLNYCF.fPEMLAEII.                                                                                                     
GCR_AOTNA          PQLTPTLVSLLEVIEPEVLYAG.sTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSY.sNLLCFAP..DLIINEQRMTLPC..MYDQCKHMLY.VSSELHRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHEVVENLLNYCF.fPEMLAEII.                                                                                                     
GCR_MOUSE          PQLTPTLVSLLEVIEPEVLYAG.sAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSY.gNLLCFAP..DLIINEQRMTLPC..MYDQCKHMLF.ISTELQRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHDVVENLLSYCF.fPEMLAEII.                                                                                                     
Q9DDU9             IQFTPELLQILQSIEPEVVYAG.tPSALLSSLNQLCERQLVCVVKWSKSLPGFRNLHIDDQITLLQYSWMSLMVFALGWRSY.gQMLYFAP..DLILNEQRMKDSS..FYTLCLSMWQ.LPQEFMKLQVTHEEFLCMKALLLLNT.sQTNFDEMRSNYIRELAKAIGLRHK.sQRFYQLTKLMDSMHELVKQLHLYCL.fPEMMSEVIS                                                                                                     
GCR_HUMAN          PQLTPTLVSLLEVIEPEVLYAG.sTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSY.aNLLCFAP..DLIINEQRMTLPC..MYDQCKHMLY.VSSELHRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHEVVENLLNYCF.fPEMLAEII.                                                                                                     
Q9DDJ4             FNTQMAFLNILESIEPEVVNAG.sAATLLTSLNELGERQLVKVVKWAKGLPGFRNLHVDDPMTVIQQSWMGVMVFALGWRSY.sRMLYFAP..DLVFNEHRMHIST..MYEHCIRMRH.ISQEFLMLQITQEEFLCMKALLLFSI.sQKYFDELRLAYINELDRLINNRMK.sQRFYHLTRLLDSLQMTVKKLHQFTF.fPEMIGEIIS                                                                                                     
Q9DEV4             IQFTPELLQILQSIEPEVVYAG.tPSALLSSLNQLCERQLVCVVKWSKSLPGFRNLHIDDQITLLQYSWMSLMVFALGWRSY.gQMLYFAP..DLILNEQRMKDSS..FYTLCLSMWQ.LPQEFMKLQVTHEEFLCMKALLLLNT.sQTNFDEMRSNYIRELAKAISLRHK.sQRFYQLTKLMDSMHELVKQLHLYCL.fPEMMSEVIS                                                                                                     
PRGR_CHICK         IPFVPPMISVLRGIEPEVVYAG.tPSSLLTSLNHLCERQLLCVVKWSKLLPGFRNLHIDDQITLIQYSWMSLMVFAMGWRSY.gQMLYFAP..DLILNEQRMKESS..FYSLCLSMWQ.LPQEFVRLQVSQEEFLCMKALLLLNT.sQSQFDEMRTSYIRELVKAIGLRQK.sQRFYQLTKLMDSMHDLVKQLHLFCL.fPEMMSEVI.                                                                                                     
O42274             IQFVPPLISVLQGIEPEVVYAG.tPSSLLTSLNQLCEKQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFALGWRSY.gQMLYFAP..DLILNEQRMKESS..FYSLCLSMWQ.LPQEFVRLQVTQEEFLCMKALLLLNT.sQSQFDEMRASYIRELVKAVGLRQK.sQRFYQLTKLMDSMHDLVKQLHLFCL.fPEMSRKLI.                                                                                                     
O97684             YECQPIFLNVLEAIEPGVVCAG.sFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFSI.nQKFFDELRMNYIKELDRIIACKRK.sRRFYQLTKL...........................                                                                                                     
GCR_TUPGB          PQLTPTPVSLLEVIEPEVLYAG.tTWRIMSALNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSY.aNLLCFAP..DLIINEQRMSLPF..MYDQCKHMLF.VSSELQRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHDVVENLLNYCF.fPEMLAEII.                                                                                                     
GCR_RAT            PQLTPTLVSLLEVIEPEVLYAG.sAWRIMTTLNMLGGRQVIAAVKWAKAILGLRNLHLDDQMTLLQYSWMFLMAFALGWRSY.gNLLCFAP..DLIINEQRMSLPC..MYDQCKHMLF.VSSELQRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHEVVENLLTYCF.fPEMLAEII.                                                                                                     
Q9PWG5             FPTQSVFLNILESIEPEVVNAG.sAATLLTSLNELGERQLFKVVKWAKGLPGFRNMHVDDQMTVIQHAWMGVMVFALGWRSY.aRMLYFAP..DLVFNDRRMRVSS..MYEHCIRMRH.MSQEFVLLQVTHQEFLCMKALLLFSI.nQKYFDDLRNTYINELDRLINCSRK.sQRFIQLTRLMDSLQPIVKKLHQFTF.fPEMIAEIIS                                                                                                     
Q28547             iqLIPPLINLLMSIEPDMVYAG.tSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSY.gQMLYFAP..DLILNEQRMKESS..FYSLCLTMWQ.IPQEFVKLQVSQEEFLCMKVLLLLNT.sQNQFEEMRSSYIRELIKAIGLRQK.sQRFYQLTKLLDNLHDLVKQLHLYCL.fPE.......                                                                                                     
GCR_CAVPO          PQLTPTLVSLLEVIEPEVIHSG.sTWRIMTTLNMLGGRQVIAAVKWAKAIPGFKNLHLDDQMTLLQYSWMFLMAFALGWRSY.gSLLCFAP..DLIINEQRMSLPW..MYDQCRYMLY.VSSELKRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSLHEIVGNLLNICF.fPEMLAEII.                                                                                                     
Q91425             VQFIPPLISILQSIEPEVVYAG.tPSILLTSLNQLCERQLLCVVKWSKSLPGFRNLHIDDQITLIQYSWMNLMVFAMAWRSY.gQMLYFAP..DLILNEDGIRQKM.sFYSLCLSMWR.IPQEFVKLQLTAEEFLCMKALLLLST.sQGQFDEMRSSYIRELVKAIGLRAK.sQRFYQLTKLMDSMHDLVKQLHLFCL.fPEMMSEVI.                                                                                                     
Q9YGV9             ihTQSMFLNILEAIEPEVVNAG.sAASLLTSLNELGERQLVKVVKWAKGMPGFRSLYVDDQMTVIQHSWMAVMVFALGWRSF.sRMLYFAP..DLVFNEHRMQVST..MYEHCIRMKN.FSQEFAMLQVSQEEFLCMKALLLFST.gQNFFDELRRSYINELDRLVSFRSK.sERFQQLTRLLDSLQPVLKKLHQFTF.fPEMISEIIS                                                                                                     
GCR_PIG            PQLTPTLVSLLEVIEPEVLYAG.sTWRIMTALNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMVFALGWRSY.aSLLCFAP..DLVINEQRMALPC..MYDQCRHMLY.VSSELQRLQVSYEEYLCMKTLLLLSS.sQELFDEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHDVVENLLNYCF...........                                                                                                     
GCR_ONCMY          PQLVPTMLSLLKAIEPEAIYSG.tSTRLMTTLNRLGGQQVVSAVKWAKSLPGFRNLHLDDQMTLLQCSWLFLMSFGLGWRSY.gGMLCFAP..DLVINDERMKLPY..MTDQCEQMLK.ISTEFVRLQVSYDEYLCMKVLLLLST.sQAVFDEIRMTYIKELGKAIVKREE.wQRFYQLTKLLDSMQEMVGGLLQICF.fPEMLAEIIS                                                                                                     
GCR_PAROL          PQLVPTMLSVLKAIEPEIIYSG.tSTRLMTTLNRLGGQQVISAVKWAKSLPGFRNLHLDDQMTLLQCSWLFLMSFSLGWRSY.gNMLCFAP..DLVINKERMKLPF..MTDQCEQMLK.ICNEFVRLQVSYDEYLCMKVLLLLST.sQAVFDEIRMTYIKELGKAIVKREE.wQRFYQLTKLLDSMQEMVEGLLQICF.fPEMLAEII.                                                                                                     
GCR_XENLA          pqLTPTLISLLEVIEPEVLYSG.tTRRLMSSLNMLGGRQVVSAVRWAKAIPGFRNLHLDDQMTLLQYSWMFLMVFALGWRSY.gSILYFAP..DLVITEDRMHLPF..MQERCQEMLK.IAGEMSSLQISYDEYLCMKVLLLMCT.sHALFEEIRMTYIKELGKAIVKREG.wQRFYQLTKLLDSMHEVAENLLAFCF.fPDMLSEIIS                                                                                                     
MCR_HUMAN          yaLTPSPVMVLENIEPEIVYAG.tAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSY.sQFLYFAP..DLVFNEEKMHQSA..MYELCQGMHQ.ISLQFVRLQLTFEEYTIMKVLLLLST.sQAAFEEMRTNYIKELRKMVTKCPN.wQRFYQLTKLLDSMHDLVSDLLEFCF.fPAMLVEIIS                                                                                                     
Q9N0W8             yaLTPSPAMVLENIEPEVVYAG.tAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSY.sQFLYFAP..DLVFNEEKMHQSA..MYELCQGMHQ.ISLQFIRLQLTFEEYTIMKVLLLLST.sQAAFEEMRTNYIKELRKMVTKCPN.wQRFYQLTKLLDSMHDLVNDLLEFCF.fPAMLVEIIS                                                                                                     
MCR_RAT            yaLTPSPAMILENIEPETVYAG.tAESLLSTLNRLAAKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSY.sQLLYFAP..DLVFNEEKMHQSA..MYELCQGMRQ.ISLQFVRLQLTFEEYSIMKVLLLLST.sQAAFEEMRTNYIKELRKMVTKCPN.wQRFYQLTKLLDSMHDLVSDLLEFCF.fPAMLVEII.                                                                                                     
Q9IAC6             PYLPPSICSVLELIEPEVVFAG.tTDHLLSSLNQLAGKQMIRVVKWAKVLPGFRGLPIEDQITLIQYSWMCLSSFSLSWRSY.gQMLYFAP..DLVFNEDRMQQSA..MYDLCLGMRQ.VSQEFVRLQLTYQEFLSMKVLLLLST.nQAAFEEMRVNYIKELRRSVGKAPT.gNRSSQLTKLLDAMHDLGGELLDFCF.fPEMLVEIIS                                                                                                     
MCR_TUPGB          yaLTPSPVMVLENIEPEIVYAG.tAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSRMCLSSFALSWRSY.sQFFYFAP..DLVFNEEKMHQSA..MYELCQGMHQ.ISLQFVRLQFTFEEYTFMEVLLLLST.sQAAFEEMRANYIKELRKMVTKCPN.wQGFYQLTKFLDSMHDLVSDLLEFCF.fPAMLVEIIS                                                                                                     
MCR_XENLA          PAITLSAAVILENIEPEIVYAG.tAENLLSSLNQLAGKQMVQVVKWAKVIPGFRNLPLEDQITLIQYSWMCLSSFALSWRSY.sQFLYFAP..DLIFNEERMRQSA..MYDLCQGMQQ.ISLEFSRLQLTFEEYTLMKVLLLLST.cQAAFEEMRVNYIKELRKVLLKSPH.wQRYFQLTKLLDSMQDLVGDLLEFCF.fPAMLVEIIS                                                                                                     
Q9IBD5             LHLSPQIISVLESIEPEVVYSG.mPNMLLNSLNRLCERQLLRIVKWSKSLPGFRSLHINDQMALIQYSWMSLMVFSLGWRSF.sDYLYFAP..DLILNEEYMRRSP..IFDLCMAMQF.IPQEFANLQVTKEEFLCMKVLLLLNT.sQPQFDEMRQNYIHELTKAIHLREN.sQRFYHLTKLMDHMHDIVKKLHLYCL.fPEMMSEVI.                                                                                                     
Q9W6F4             fhSCLSLLSILQAIEPALVNAG.sPVSLPTSLNELGERQLVTVVHWAKAIPGFRDLYVDDQMSLIQLSWMGVMVFALGWRSY.sSMLYFAP..DLVFNDQRMQVSS..MYEHCVRMKL.LSQRLCMLKVTQEEFLCMKALVLLSI.sQSCFDKLRTSYIKELDRLASHHGE.tQRLFQLTQLLDYLQSVVRKLHQFTY.fPEMISEIVS                                                                                                     
Q9BDJ7             laLTPSPSMILETIQPEIVYAG.tADNLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSY.pQFLYFPP..DLVFNEKKMHHSA..MFELCQGMHH.ILLQFVRLHLTSEEYSIIKVLLLLST.tQAVFEEMRTNNIKELRKMVTKCPN.wQSFYQLTKLLDSMHELVSDLLEFCF.fPAMLVEIIS                                                                                                     
Q9IA30             feCQPIFLNVLEAIEPGVVCAG.sFAALLTSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAIIQYSWMGLMIFAMGWRSF.sRMLYFAP..DLVFNEYRMHKSR..MYSQCVRMRH.LSQEFGWLQITPQEFLCMKALLLFS.................................................................                                                                                                     




Profile: hPPARd (based on 3D structure) Number of sequences aligned: 41



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
PPAS_HUMAN         VADLKAFSKHIYNAYLKNFNMT.iSVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVN.KDGLLVAN.GSGFVTREFLRSLRKPFSDIIEPKFE.FAVKFNALELDDSDLALFIAAIILCG.nVPRVEAIQDTILRALEFHLQANHP.qYLFPKLLQKMADLRQLVTEHAQMMQ.lHPLLQEIY.                             
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252

PPAS_MOUSE         vaDLKAFSKHIYNAYLKNFNMT.iSVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVN.KDGLLVAN.GSGFVTHEFLRSLRKPFSDIIEPKFE.FAVKFNALELDDSDLALFIAAIILCG.nVPQVEAIQDTILRALEFHLQVNHP.qYLFPKLLQKMADLRQLVTEHAQMMQ.lHPLLQEIY.                                                                                                            
Q99ND3             vaDLKAFSKHIYNAYLKNFNMT.iSVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVN.KDGLLVAN.GSGFVTHEFLRSIRKPFSDIIEPKFE.FAVKFNALELDDSDLALFIAAIILCG.nVPQVEAIQDTILQALEFHLQVNHP.qYLFPKLLQKMADLRQLVTEHAQMMQ.lHPLLQEIY.                                                                                                     
Q62879             vaDLKAFSKHIYNAYLKNFNMT.iSVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVN.KDGLLVAN.GSGFVTHEFLRSIRKPFSDIIEPKFE.FAVKFNALELVDSDLALFIAAIILCG.nVPQVEAIQDTILQALEFHLQVNHP.qYLFPKLLQKMADLRQLVTEHAQMMQ.lHPLLQEIY.                                                                                                     
Q9QWI0             vaDLKAFSKHIYNAYLKNFNMT.iSVHVFYRCQSTTVDTVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHQAIFAMLASIVN.KDGLLVAN.GSGFVTHEFLRSIRKPFSDIIEPKFE.FAVKFNALELDDSDLALFIAAIILCG.nVPQVEAIQDTILQALEFHLQVNHP.qYLFPKLLQKMADLRQLVTEHAQMMQ.lHPLLQEIY.                                                                                                     
Q9N2H4             VADLKAFSKHIYNAYLKNFNMT.iSVHVFYRCQYTTVETVRELTEFAKSIPNFSSLFVNDQVTVVKYGVHEAIFAMLASIVN.KDGLLVAN.GSGFVTREFLRSLRKPFSDIIEPKFE.FAVKFNALELDDSDLALFIAAIILCG.nVPQVEAIQDTILRALEFHLQANHP.qYFFPKLLQKMADLRQLVTEHAQMMQ.lHPLLQEIY.                                                                                                     
Q9MZG4             VADLKAFSKHLYSAYLKNFNMT.iSVHVFYRCQCTTVETVRELTEFAKSIPSFDHLFLNDQVTLLKYGVHEAIFAMLASIVN.KDGLLVAN.GTGFVTREFLRDLRKPFSDIIEPKFE.FAVKFNALELDDSDLALFIAAIILCG.nVSQVEAIQDTILRALEFHLQANHP.qYLFPKLLQKMADLRQLVTEHAQMMQ.lHPLLQEIY.                                                                                                     
Q9N128             VADLRAFSKHIYSAYLKNFNMT.iSVHVFYRCQCTTVETVRELTEFAKSIPSFGDLFLNDQVTLLKYGVHEAIFAMLASIVN.KDGLLVAN.GTGFVTREFLRSLRKPFSDIIEPKFE.FAVKFNALELDDSDLALFIAAIILCG.nVSQVEAIQDTILRALEFHLQANHP.qYLFPKLLQKMADLRQLVTEHAQMMQ.lHPLLQEI..                                                                                                     
Q9I8W3             VADLKAFSKHIYNAYLKNFNMT.iGVHVFYRCQCTTVETVRELTEFAKSIPSFIGLYLNDQVTLLKYGVHEAIFAMLASIMN.KDGLLVAN.GNGFVTREFLRTLRKPFNEIMEPKFE.FAVKFNALELDDSDLSLFVAAIILCG.nVKQVEEIQDNILRALEFHLQSNHP.qYLFPKLLQKMADLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
Q9PU75             VADLKAFSKHIYNAYLKNFNMT.iGVHVFYRCQCTTVETVRELTEFAKSIPSFVGLYLNDQVTLLKYGVHEAIFAMLASIMN.KDGLLVAN.GNGFVTREFLRSLRKPFNEIMEPKFE.FAVKFNSLELDDSDLALFVAAIILCG.nVKLVEDIQDNILRALEFHLQTNHP.qYLFPKLLQKMADLRQLVTEHAQLVQ.lHPLL.....                                                                                                     
Q9GLG8             .......................iSVHVFYRCQYTTVETVRELTEFAKSIPSFSNLFLNDQVTLLKYGVHEAIFAMLASIVN.KDGLLVAN.GTGFVTREFLRSLRKPFSDIIEPKFE.FAVKFNALELDDSDLALFIAAIILCG.nVPQVEAIQDTILRALEFHLQANHP.qYLFPKLLQKMADLRQLVTERAQMMQ...........                                                                                                        
Q9I8W4             vaDLKSLAKRIHDAYLKNFNMN.aEVRIFHCCQCTSVETVTELTEFAKSIPGFSNLDLNDQVTLLKYGVYEAIFAMLASVMN.KDGMLVAY.GNGFITREFLKSLRKPFCDIMEPKFD.FAMKFNALELDDSDISLFVAAIICCG.nVGHIEKMQESIVHVLKLHLQTNHP.iFLFPKLLQKMADLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
Q9N129             vaDLKSLAKRIYEAYLKNFNMN.aEVRIFHCCQCTSVETVTELTEFAKSIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMN.KDGMLVAY.GNGFITREFLKSLRKPFCDIMEPKFD.FAMKFNALELDDSDISLFVAAIICCG.nVGHIEKMQEGIVHVLKLHLQNNHP.vFLFPKLLQKMADLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
Q9PU76             laDLKSLAKQIYEAYLKNFNMN.aEVRIFHCCQCTSVETVTELTEFAKSIPGFSNLDLNDQVTLLKYGVYEAIFAMLASVMN.KDGMPVAY.GNGFITREFLKSLRKPFCDIMEPKFD.FAMKFNSLELDDSDISLFVAAIICCG.nVGHIEKMQESIVHVLKLHLQNNHP.iFLFPKLLQKMADLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
PPAR_HUMAN         vaDLKSLAKRIYEAYLKNFNMN.aEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMN.KDGMLVAY.GNGFITREFLKSLRKPFCDIMEPKFD.FAMKFNALELDDSDISLFVAAIICCG.nVGHIEKMQEGIVHVLRLHLQSNHP.iFLFPKLLQKMADLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
PPAS_XENLA         VSDLDVLSQLIHSSYMNTFTMT.iGVHVFYRCQCTSVETVRALTDFAKRIPGFGTLYLNDQVTLLKYGVHEAIFCMLASLMN.KDGLLVAG.GRGFVTREFLRSLRQPFCHIMEPKFH.FASKFNALELNDSDLALFVASIILCG.nPSQVEDIQEGILGALRRHLKASHT.pFLFPKLLHKMADLRQLVTEHAELVQ.lHPLLQEIY.                                                                                                     
PPAR_XENLA         vaDLLSLARLIYDAYLKNFNMN.aEVRIFHCCQCTSVETVTELTEFAKSIPGFTELDLNDQVTLLKYGVYEAMFAMLASVMN.KDGMLVAY.GNGFITREFLKSLRKPIGDMMEPKFE.FAMKFNALELDDSDLSLFVAALICCG.nIPSIEKMQESIVHVLKLHLQSNHP.sFLFPKLLQKMADLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
Q9N135             vaDLKSLAKRIYEAIKKNFNMN.aEVRIFHCCQCTSDVSVTELTEFAKSIXGFASLDLNDQVTLLKYGVYDAIFAMLSSVMN.KDGMLVAY.GNGFITREFLKSLRKPFCDIMEPKFD.FAMKFNALELDDSDLSLFVAAIICCG.nVGHIERMQEGIVHVLKLHLQTNHP.vFLFPKLLQKLADLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
PPAR_RAT           vaDLKSLAKRIHEAYLKNFNMN.aEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMN.KDGMLIAY.GNGFITREFLKNLRKPFCDIMEPKFD.FAMKFNALELDDSDISLFVAAIICCG.nIGYIEKLQEGIVHVLKLHLQSNHP.tFLFPKLLQKMVDLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
PPAR_MOUSE         vaDLKSLGKRIHEAYLKNFNMN.aEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMN.KDGMLIAY.GNGFITREFLKNLRKPFCDIMEPKFD.FAMKFNALELDDSDISLFVAAIICCG.nIGYIEKLQEGIVHVLKLHLQSNHP.tFLFPKLLQKMVDLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
PPAR_CAVPO         vaDLKSLAKRIYEAYLKNFHMN.aEVRIFHCCQCVSVETVTNLTEFAKAIPGFASLDLNDQVTLLKYGVYEAIFTMLSSTMN.KDGMLVAY.GHGFITREFLKNLRKPFCDMMEPKFN.FAMKFNALELDDSDISLFVAAIICCG.nIDHIEKMQEAIVHVLKLHLQSNHP.tFLFPKLLQKLADLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
O70527             vaDLKSLAKRIYEAYLKNFHMK.aEVRIFHCCQCVSVETVTNLTEFAKAIPGFASLDLNDQVTLLKYGVYEAIFTMLSSTMN.KDGMLVAY.GHGFITREFLKNLRKPFCDMMEPKFN.FAMKFNALELDDSDISLFVAAIICCG.nIDHIEKMQEAIVHVLKLHLQSNHP.tFLFPKLLQKLADLRQLVTEHAQLVQ.lHPLLQEIY.                                                                                                     
Q9BUD4             VADLKAFSKHIYNAYLKNFNMT.iSVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVN.KDGLLVAN.GSGFVTREFLRSLRKPFSDIIEPKFE.FAVKFNALELDDSDLALFIAAIILCG.....GE.........................................................                                                                                                     
Q98SF8             vaDQRVLAKHLYDSYVKSFPLT.vAIRIFQRCQSRSAEAVREITEFAKNIPGFVSLDLNDQVTLLKYGVHEIIFTMLASLMN.KDGVLVAE.GQGFMTREFLKSLRKPFSDFMEPKFE.FAIRFNSLELDDSDLAIFVAVIILSG.nVKPIEDIQDSLLQALELQLKLNHP.aQLFAKLLQKMTDLRQVVTEHVQLLQ.lHPLLQEIY.                                                                                                     
Q9I878             vaDLRALAKHLYDSYIKSFPLT.vAIRIFQRCQFRSVEAVQEITEFAKNIPGFVNLDLNDQVTLLKYGVHEIIYTLLASLMN.KDGVLISD.GQGFMTREFLKSLRKPFCDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKLLQKMTDLRQIVTEHVQLLQ.lHPLLQEIY.                                                                                                     
PPAT_RABIT         vaDLRALAKHLYDSYIKSFPLT.vAIRIFQGCQFRSVEAVQEITEYAKNIPGFVSLDLNDQVTLLKYGVHEIIYTMLASLMN.KDGVLISE.GQGFMTREFLKSLRKPFGDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKLLQKMTDLRQIVTEHVQLLQ.lHPLLQEIY.                                                                                                     
PPAT_HUMAN         laDLRALAKHLYDSYIKSFPLT.vAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN.KDGVLISE.GQGFMTREFLKSLRKPFGDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKLLQKMTDLRQIVTEHVQLLQ.lHPLLQEIY.                                                                                                     
PPAT_MACMU         laDLRALAKHLYDSYIKSFPLT.vAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN.KDGVLISE.GQGFMTREFLKSLRKPFGDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKLLQKMTDLRQIVTEHVQLLQ.lHPLLQEIY.                                                                                                     
PPAT_BOVIN         laDLRALAKHLYDSYIKSFPLT.vAIRIFQGCQFRSVEAVQEITEYAKNIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN.KDGVLISE.GQGFMTREFLKSLRKPFGDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKLLQKMTDLRQIVTEHVQLLQ.lHPLLQEIY.                                                                                                     
PPAT_PIG           laDLRALAKHLYDSYIKSFPLT.vAIRIFQGCQFRSVEAVQEITEYAKNIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN.KDGVLISE.GQGFMTREFLKSLRKPFGDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKLLQKMTDLRQIVTEHVQLLQ.lHPLLQEIY.                                                                                                     
PPAT_CRIGR         vaDLRALAKHLYDSYIKSFPLT.vAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMN.KDGVLISE.GQGFMTREFLKSLRKPFGDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKVLQKMTDLRQIVTEHVQLLH.lHPLLQEIY.                                                                                                     
PPAT_RAT           laDLRALAKHLYDSYIKSFPLT.vAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMN.KDGVLISE.GQGFMTREFLKSLRKPFGDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKVLQKMTDLRQIVTEHVQLLH.lHPLLQEIY.                                                                                                     
Q99PC7             vaDLRALAKHLYDSYIKSFPLI.vAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMN.KDGVLISE.GQGFMTREFLKSLRKPFGDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKVLQKMTDLRQIVTEHVQLLH.lHPLLQEIY.                                                                                                     
Q9PU74             vaDLRALAKHLYDSYIKSFPLT.vAIRIFQRCQFRSVEAVQEXTEFAKNIPGFVNLDLNDQVTLLKYGVHEIIYTLLASLMN.KDGVLISD.GQGFMTREFLKSLRKPFCDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKLLQKMTDLRQIVTEHVQLLQ.lHPLL.....                                                                                                     
PPAT_MOUSE         laDLRALAKHLYDSYIKSFPLT.vAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMN.KDGVLISE.GQGFMTREFLKNLRKPFGDFMEPKFE.FAVKFNALELDDSDLAIFIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKVLQKMTDLRQIVTEHVQLLH.lHPLLQEIY.                                                                                                     
PPAT_XENLA         vaDQRVLAKHLYDSYVKSFPLT.gGDSNLPALSVALRGGVREITEFAKNIPGFVSLDLNDQVTLLKYGVHEIIFTMLASLMN.KDGVLVAE.GQGFMTREFLKSLRKPFSDFMEPKFE.FAIRFNSLELDDSDLAIFVAVIILSG.nVKPIEDIQDSLLQALELQLKLNHP.aQLFAKLLQKMTDLRQVVTEHVQLLQ.lHPLLQEIY.                                                                                                     
Q9PU26             vaDLRALAKNLYDSYIKSFPLT.vAIRIFQRCQFRSVEAVQEITEFAKSIPGFVNPDLNDQVTLLKYGVHEIIYTLLASLMN.KDGVLISN.GQGFMTREFLKSLRKPFCDFMEPKFE.FAVKFNALELDDSDLAIIIAVIILSG.nVKPIEDIQDNLLQALELQLKLNHP.sQLFAKLLQKMTDLRQIVTEHVQLLQ.lHPLL.....                                                                                                     
Q9PW01             vaDLRALARHLYEAYLKYFPLT.lELRFFQSCQSRSAEAVREVTEFAKSIPGFTDLDLNDQVTLLKYGVIEVLIIMMSPLMN.KDGTLISY.GQIFMTREFLKSLRKPFCQMMEPKFE.FSVKFNTLELDDSDMALFLVVIILSG.nVKPIEQLQETVLHSLELQLKLNHP.lQLFAKLLQKMTDLRQIVTDHVHLIQ.lHPLLQEIM.                                                                                                     
Q9W712             vaDLRALARHLYEAYLKYFPLT.lELRFFQSCQSPSAEAVREVTEFAKSIPGFTDLDLNDQVTLLKYGVIEVLIIMMSPLMN.KDGTLISY.GQIFMTREFLKSLRKPFCQMMEPKFE.FSVKFNTLELDDSDMALFLVVIILSG.nVKPIEQLQETVLHSLELQLKLNHP.lQLFAKLLQKMTDLRQIVTDHVHLIQ.lHPLLQEIM.                                                                                                     
Q9I8F6             laDLRALSRQLCLSYHRHFPLT.lELSVFRRIQFRSAEAVQEVTEFTKSIPGFTELDMNDQVILLKYGVIEVMTTMLAPLMN.KDGTLFAY.GQIFMTREFLKSLRKPFCEMMEPKFE.FAAKFNLLELDDSDMALFFAVIILSG.nVKPIEDLQETVLQALELQLKTIHP.pQLFAKLLQKMTDLRQLGGQPRSAHI.lHPLLQEIM.                                                                                                     
Q9I8F7             laDLRALSRQLCLSYHRHFPLT.lELSVFRRIQFRSAEAVQEVTEFTKSIPGFTELDMNDQVILLKYGVIEVMTTMLAPLMN.KDGTLFAY.GQIFMTREFLKSLRKPFCEMMEPKFE.FAAKFNLLELDDSDMALFFAVIILSG.nVKPIEDLQETVLQALELQLKTIHP.pQLFAKLLMQQ..........................                                                                                                     




Profile: hVDR (based on 3D structure) Number of aligned sequences: 11



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
VDR_HUMAN          SEEQQRIIAILLDAHHKTYDPT.sQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT.dMSWTCGN.QDYKYRVSDVTKAG.HSLELIEPLIK.FQVGLKKLNLHEEEHVLLMAICIVSP.dAALIEAIQDRLSNTLQTYIRCRHP.hLLYAKMIQKLADLRSLNEEHSKQYR.lTPLVLEVFG                                                                                  
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252     

VDR_COTJA          SEEQQKVINILLEAHHKTFDTT.pHLPMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFT.dMSWTCGS.NDFKYKVSDVTQAG.HSMDLLEPLVK.FQVGLKKLNLHEEEHVLLMAICILSP.dTSLVESIQDRLSDTLQTYIRCRHP.rLLYAKMIQKLADLRSLNEEHSKQYR.lTPLVLEVFG                                                                                                     
Q9IB73             teEQARMISSLVEAHHKTYDAS.tKLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFS.dMSWSCGG.PDFKYCINDVTKAG.HTLELLEPLVK.FQVGLKKLNLHEEEHVLLMGICLLSP.dHARVEQLQDRLPEALQAYIRINHP.rLLYAKMIQKLADLRSLNEEHSKQYR.lTPLVLEVFG                                                                                                     
VDR_CHICK          SEEQQKVIDTLLEAHHKTFDTT.pHLPMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEVIMLRSNQSFT.dMSWTCGS.NDFKYKVSDVTQAG.HSMDLLEPLVK.FQVGLKKLNLHEEEHVLLMAICILSP.dTSLVESIQDRLSDILQTYIRCRHP.rLLYAKMIQKLADLRSLNEEHSKQYR.lTPLVLEVFG                                                                                                     
VDR_BOVIN          SEEQQRIIAILLDAHHKTYDPT.sQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFT.dMSWTCGN.QDYKYRVSDVTKAG.HSLELIEPLIK.FQVGLKKLNLHEEEHVLLMAICIVSP.dAALIEAIQDRLSNTLQTYIRCRHP.hLLYAKMIQKLADLRSLNEEHSKQYR.lTPLVLEVFG                                                                                                     
VDR_RAT            teEQQHIIAILLDAHHKTYDPT.sPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFT.dMSWDCGS.QDYKYDVTDVSKAG.HTLELIEPLIK.FQVGLKKLNLHEEEHVLLMAICIVSP.dAKLVEAIQDRLSNTLQTYIRCRHP.hQLYAKMIQKLADLRSLNEEHSKQYR.lTPLVLEVFG                                                                                                     
Q9PTN2             tdEQMQIINSLVEAHHKTYDDS.sRLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFS.dMSWSCGG.PDFKYCINDVTKAG.HTLELLEPLVK.FQVGLKKLKLHEEEHVLLMAICLLSP.dHVRIEALQDRLCDVLQAYIRIQHP.rLLYAKMIQKLADLRSLNEEHSKQYR.lTPLVLEVFG                                                                                                     
VDR_MOUSE          SEEQQHIIAILLDAHHKTYDPT.sPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFT.dMSWDCGS.QDYKYDITDVSRAG.HTLELIEPLIK.FQVGLKKLNLHEEEHVLLMAICIVSP.dAKLVEAIQDRLSNTLQTYIRCRHP.hQLYAKMIQKLADLRSLNEEHSKQYR.lTPLVLEVFG                                                                                                     
VDR_XENLA          tdEQQKMIDILLEAHRKTFDTT.gELSMLPHIADLVSYSIQKIIGFAKMIPGFRDLIAEDQIALLKSSVIEVIMLRSNQSFS.dMSWTCGS.EDFKYKVDDVTQAG.HNMELLEPLVK.FQVGLKKLDLHEEEHVLLMAICILSP.dKALVESIQDRLSSTLQTYILCKHP.rLLYAKMIQKLADLRSLNEEHSKQYR.lTPLMLEVFS                                                                                                     
Q9IB74             TDEQSQVIAMLVEAHHKTYDDS.sSFSMLPHLADLVSYSIQKVIGFAKMIPGFRELTAEDQIALLKSSAIEVIMLRSNQSFN.dMSWSCGA.PDFKYQISDVTKAG.HTLELLEPLVK.FQVGLKKLNLQEEEHVMLMAICLLSP.dHARIEALQDRLSETLQAYIQLHHP.rLLYAKMIQKLADLRSLNEEHSKQYR.lTPLVLEVSG                                                                                                     
Q91839             TPEQQHFLTQLVGAHTKTFDFN.eAFLMLPHISDLVTYMIKGIISFAKMLPYFKSLDIEDQIALLKGSVAEVSVIRFNTVFN.tNTWECG...PFTYDTEDMFLAG.FRQLFLEPLVR.IHRMMRKLNLQSEEYAMMAALSIFAS.dWEKIQKLQEHIALTLKDFIDSQRP.rLLYPKIMECLTELRTVNDIHSKQLL.aTPLMREVFG                                                                                                     
Q9DFH3             TAEQQELISILIAAHKRTFDS..dVFSILPHFADLSTFMIQQVIKFAKEIPAFRGLPIDDQISLLKGATLGICQIQFNTVF..tNAWECG...QHCFTIKDGALAG.FQQIYLEPLLK.FHISLKKLRLHEAEYVLLVAMLLFS..qRDFIDQLQEKVALTLKSYIDHRH..rFLYAKLLLLLTELQTLKMENTRQI..mTPLLSEIIS                                                                                                     
Q9DF24             TPEQQHFITELVEAHTKTFDF..eAFLMLPHISDLFTYMLKGVISFAKMLPYFRSLAIEDQIALLKGSVLEVCVIRFNRMF..tNTWECG...AFTYNADDMTMAG.FSQQFLEPLLR.IHCMMTKLNLESEAYALMATMALFS..dCEKIQNLQEHIALMLKAFIESHR..rLLYPKIMECLTELRTINDIHSKQL..vTPLMREVF.                                                                                                     
NRI3_HUMAN         SKEQEELIRTLLGAHTRHMGT..pVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTF..tQNFLCG...PLRYTIEDGARVG.FQVEFLELLFH.FHGTLRKLQLQEPEYVLLAAMALFS..qRDEIDQLQEEMALTLQSYIKGQQ..rFLYAKLLGLLAELRSINEAYGYQI..mMPLLQEICS                                                                                                     
NRI3_RAT           SQQQKELIQTLLGAHTRHVGP..pVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTF..tQNFFCG...PLCYKMEDAVHVG.FQYEFLELIIH.FHKTLKRLQLQEPEYALMAAMALFS..qREEIDQLQEEVALILNNHIMEQQ..rFLYAKLMGLLAELRSINSAYSYEI..mMPLLGEICS                                                                                                     
NRI3_MOUSE         NQQQKELVQILLGAHTRHVGP..pVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTF..tENFFCG...PLCYKMEDAVHAG.FQYEFLESILH.FHKNLKGLHLQEPEYVLMAATALFS..qREEIDQLQEEMALILNNHIMEQQ..rFLYAKLMGLLADLRSINNAYSYEL..mTPLLGEICS                                                                                                                               




Profile: hTRb (based on 3D structure) Number of sequences aligned: 36



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
THB1_HUMAN         TDEEWELIKTVTEAHVATNAQG.vDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGMSLSSFNLDDTEVALLQAVLLMSS.cVERIEKYQDSFLLAFEHYINYRKH.tHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                           
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252     

THA_CHICK          SAEEWELIHVVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVDKIEKCQETYLLAFEHYINYRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THA_CAIMO          SAEEWELIHVVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVDKIEKCQETYLLAFEHYINYRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEV..                                                                                                     
THA_APTPA          SAEEWELIHVVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVEKIEKCQETYLLAFEHYINYRKH.pHFWPKLLMKVTDLRMIRACHASRFL.fPPLFLEV..                                                                                                     
THA_RANCA          SSEEWELIRIVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGRSLSAFNLDDTEVALLQAVLLMSS.cTDKIEKCQETYLLAFEHYINHRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THAA_XENLA         SSEEWELIRIVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELTCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGRSLAAFNLDDTEVALLQAVLLMSS.cTDKIEKCQETYLLAFEHYINHRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THAB_XENLA         SSEEWELIRIVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELTCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGRSLAAFNLDDTEVALLQAVLLMSS.cTDKIEKCQETYLLAFEHYINHRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB_CHICK          TDEEWELIKIVTEAHVATNAQG.vDLEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGMSLSSFNLDDTEVALLQAVLLMSS.cVERIEKCQEGFLLAFEHYINYRKH.aHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THA_PYGAD          SAEEWELIHVVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.gGTLTLSG..EMAVKREQLKNGG..LRVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVEKIEKCQETYLLAFEHYINYRKH.pHFWPKLLMKVTDLRMIRACHASRFL.fPPLFLEV..                                                                                                     
THAB_PAROL         TGAEWELIRMVTEAHRHTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSelPCEDQIILLKGCCMEIMSLRAAMRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLAQFNLDDTEVALLQAVLLMSS.cMDKIEKCQETYLLAFEHYINYRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB1_RAT           TDEEWELIKTVTEAHVATNAQG.vDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGMSLSSFNLDDTEVALLQAVLLMSS.cVERIEKYQDSFLLAFEHYINYRKH.tHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB1_MOUSE         TDEEWELIKTVTEAHVATNAQG.vDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGMSLSSFNLDDTEVALLQAVLLMSS.cVERIEKYQDSFLLAFEHYINYRKH.tHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB2_MOUSE         TDEEWELIKTVTEAHVATNAQG.vDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGMSLSSFNLDDTEVALLQAVLLMSS.cVERIEKYQDSFLLAFEHYINYRKH.tHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB2_RAT           TDEEWELIKTVTEAHVATNAQG.vDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGMSLSSFNLDDTEVALLQAVLLMSS.cVERIEKYQDSFLLAFEHYINYRKH.tHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB_RANCA          TPEEWELIQVVTEAHVATNAQG.vDLEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGVSLSSFNLDDTEVALLQAVLLMSS.sVERIEKCQEGFLLAFEHYINYRKH.aHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THA_SALSA          ssSEWELIRHVTEAHRHTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLAQFNLDDSEVALLQAVLLMSS.lVDKIEKCQETYLLAFEHYINHRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB2_HUMAN         TDEEWELIKTVTEAHVATNAQG.vDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LQMSLSSFNLDDTEVALLQAVLLMSS.cVERIEKYQDSFLLAFEHYINYRKH.tHFWPKLLMKVTDLRMIGACHASRFL.lPPLFLEVFE                                                                                                     
THBB_XENLA         TQEEWELIQVVTEAHVATNAQG.vDLEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGVSLSSFSLDDTEVALLQAVLLMSS.sVERIEKCQEGFLLAFEHYINYRKH.aHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THBA_XENLA         TQEEWELIQVVTEAHVATNAQG.vDLEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGVSLSSFSLDDTEVALLQAVLLMSS.sVERIEKCQEGFLLAFEHYINYRKH.aHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THA1_SHEEP         TPEEWDLIHVATEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sDTLTLSG..EMAVKREQLKNGG..LGVVSDAIFE.LGKSLSAFNLDDTEVALLQAVLLMST.cVDKIEKSQEAYLLAFEHYVNHRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
Q96593             taEEWELIHVVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKNLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVDKIEKCQESYLLAFEHYINYRKH.pHFWPKLLMKVADLRMIGAYHASRFL...........                                                                                                     
Q96594             taEEWELIHVVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKNLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVDKIEKCQESYLLAFEHYINYRKH.pHFWPKLLMKVADLRMIGAYHASRFL...........                                                                                                     
THA1_BRARE         TVSEWELIRMVTEAHRHTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVSREQLKNGG..LGVVSDAIFD.LGKSLSQFNLDDSEVALLQAVLLMSS.cVEKIEKCQEMYLLAFEHYINHRKH.sHFWPKLLMKVTNLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
O36200             taEEWELIHVVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKNLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVDKIEKCQESYLLAFEHYINYRKH.pHFWSKLLMKVADLRMIGAYHASRFL...........                                                                                                     
ERBA_AVIER         SAEEWELIHVVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKNLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVDKIEKCQESYLLAFEHYINYRKH.pHFWSKLLMKVADLRMIGAYHASRFL...........                                                                                                     
Q85511             taEEWELIHVVTEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKNLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVDKIEKCQESYLLAFEHYINYRKH.pHFWSKLLMKVADLRMIGAYHASRFL...........                                                                                                     
Q64895             taEEWELIHVVTEAHRSTNAQG.vDLEAFTEFTKIITPAITRVVDFAKNLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLSAFNLDDTEVALLQAVLLMSS.cVDKIEKCQESYLLAFEHYINYRKH.pHFWSKLLMKVADLRMIGAYHASRFL...........                                                                                                     
THA_HIPHI          stAEWELIRMATDAHRHTNAQG.vDLEAFSEFTKIMTPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLAQFNLDDTEVALMQAVLLMSS.sLEKIEQCQEAYLLAFEHYINYRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THAA_PAROL         stAEWELIRMATDAHRHTNAQG.vDLEAFSEFTKIMTPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNS..EMAVKREQLKNGG..LGVVSDAIFD.LGKELGQFNLDDTEVALMQAVLLMSS.cMEKIEQCQEAYLLAFEHYINYRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB_PAROL          TQEEWDLIRMVTEAHMATNAQG.vDIEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGVSLSSFNLDDSEVALLQAVILLSS.sVERIEPCQEEFLLAFEHYINYRKH.aHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB_BRARE          TQEEWEMIRVVTEAHMATNAQG.vDIEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sDTLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGVSLSSFNLDDSEVALLQAVILLSS.sVERIERCQEEFLLAFEHYINYRKH.aHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THA_ONCMY          .......................vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLSG..EMAVKREQLKNGG..LGVVSDAIFD.LGKSLAQFNLDDSEVALLQAVLLMSS.sVDKIEKCQETYLLAFEHYINHRKH.pHFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THA_PIG            TPEEWDLIHVATEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sDTLTLSG..EMAVKREQLKNGG..LGVVSDAIFE.LGKSLSAFNLDDTEVALLQAVLLMST.cVDKIEKSQEAYLLAFEHYVNHRKH.pHFWPKLLMK...........................                                                                                                     
THA_HUMAN          TPEEWDLIHIATEAHRSTNAQG.vDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD.sDTLTLSG..EMAVKREQLKNGG..LGVVSDAIFE.LGKSLSAFNLDDTEVALLQAVLLMST.cVDKIEKSQEAYLLAFEHYVNHRKH.pHFWPKLLMK...........................                                                                                                     
O73764             .......................vDIEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRGQLKNGG..LGVVSDAIFD.LGLSLSSFHLDDSEVALLQTVILLSS.sVDRIERCQEEFLLAFEHYINYRKH.aQFWPKLLMKVTDLRMIGACHASRFL.fPPLFLEVFE                                                                                                     
THB1_SHEEP         TDQEWELIKTVTEAHVATNAQG.vDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD.sETLTLNG..EMAVTRRQLKNGG..LGVVSDAIFD.LGMSLSSFNLDDTEVALLQAVLLMSS.cVERIEKYQDSFLLAFEHYINYRRN.S....................................                                                                                                     




Profile: hRARa (bases on 3D structure) Number of sequences aligned: 34



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
RRA_HUMAN          TPEVGELIEKVRKAHQETFPAL.lDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLICG.qPDRVDMLQEPLLEALKVYVRKRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.    
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252                                                                                                 

Q90966             TPEVEELIEKVRKAHQETFPAL.lDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLICG.qPDKVDKLQEPLLEALKIYVRKRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
RRA_NOTVI          TPEVEDLVEKVRKAHQETFPAL.lDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLICG.qPDKVDKLQEPLLEALKIYVRKRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
RRA_MOUSE          TPEVGELIEKVRKAHQETFPAL.lDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLICG.qPDKVDMLQEPLLEALKVYVRKRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
P97513             TPEVGELIEKVRKAHQETFPAL.lDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLICG.qPDKVDMLQEPLLEALKVYVRKRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
Q15156             TPEVGELIEKVRKAHQETFPAL.lDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLICG.qPDRVDMLQEPLLEALKVYVRKRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
Q9QWJ1             TPEVGELIEKVRKANQETFPAL.lDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLICG.qPDKVDMLQEPLLEALKVYVRKRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
Q92019             SPETQDLIEKVRKAHKETFPAL.lDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKSACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLICG.qPDKVDKLQEPLLEALKIYVRNRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
RRB_HUMAN          TAELDDLTEKIRKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFT.FANQLLPLEMDDTETGLLSAICLICG.ePTKVDKLQEPLLEALKIYIRKRRP.pHMFPKILMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
RRB_MOUSE          TAELDDLTEKIRKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFT.FANQLLPLEMDDTETGLLSAICLICG.ePTKVDKLQEPLLEALKIYIRKRRP.pHMFPKILMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
Q9W6B3             TAELDDLTEKIRKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFTSLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFT.FANQLLPLEMDDTETGLLSAICLICG.ePMKVDKLQEPLLEALKIYIRKRRP.pHMFPKILMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
RRB_CHICK          TAELDDLTEKIRKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFTSLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFT.FANQLLPLEMDDTETGLLSAICLICG.ePMKVDKLQEPLLEALKIYIRKRRP.pHMFPKILMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
Q90272             SPDTEKMIEQVRKAHQETFPSL.lDVDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLLCG.qSDKVDELQEPLLEALKIYVRNRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
Q91391             SPDTEQMIDRVRKAHQETFPSL.lDVDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLLCG.qADKVDVLQEPLLEALKIYVRNRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
Q9I8T2             PPEMEALIAKVSKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFATLTIADQITLLKAACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAEQLLPLEMDDTETGLLSAICLICG.ePEKVDKLQEPLLEALKIYARRRRP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
Q9I8T3             PPEMEALIAKVSKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFATLTIADQITLLKAACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAEQLLPLEMDDTETGLLSAICLICG.ePEKVDKLQEPLLEALKIYARRRRP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
RRG_BRARE          SGELEELVNKVSKAHQETFPSL.lDLGLWDKFSELSTKCIIKIVEFAKRLPGFTTLTIADQITLLKSACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAGQLLPLEMDDTETGLLSAICLICG.ePERVDRLQEPLLEALKIYARRRRP.pHMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
RRG1_HUMAN         SPQLEELITKVSKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAGQLLPLEMDDTETGLLSAICLICG.ePEKVDKLQEPLLEALRLYARRRRP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
RRG2_HUMAN         SPQLEELITKVSKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAGQLLPLEMDDTETGLLSAICLICG.ePEKVDKLQEPLLEALRLYARRRRP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
Q9W5Z3             SPDTEQMINRVRKAHQETFPSL.lDVDLWDKFSELSTKCIIKTVEFAKQLPGFVTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLLCG.qAEKVDILQEPLLEALKIYVRRRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
RRG_NOTVI          PPEMEALIQKVSKAHQETFPSL.lDLGLWHKFSELATKCIIKIVEFAKRLPGFATLTIADQITLLKAACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAEQLLPLEMDDTETGLLSAICLICG.ePEKVDKLQEPLLEALKIYARRRRP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
RRG1_XENLA         PPEMEELIQKVSKAHQETFPSL.lDLGLWDKFSELSTKCIIKIVEFAKRLPGFTTLTIADQITLLKSACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFS.FADQLLPLEMDDTETGLLSAICLICG.ePEKVEKLQEPLLEALKFYARRRRP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
Q9UJ38             SPQLEELITKVSKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFAGLSIADQITLLKAACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAGQLLPLEMDDTETGLLSAICLICG.ePEKVDKLQEPLLEALRLYARRRRP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
RRG1_MOUSE         SPQLEELITKVSKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAGQLLPLEMDDTETGLLSAICLICG.ePEKVDKLQEPLLEALRLYARRRDP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
RRG2_MOUSE         SPQLEELITKVSKAHQETFPSL.lDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAGQLLPLEMDDTETGLLSAICLICG.ePEKVDKLQEPLLEALRLYARRRDP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
Q90271             SPDTEQMIDRVRKAHQETFPSL.lDVDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLLCG.qADKVDVLQEPLLEALKIYVRNRRP.pHMFPKMLMKITDLRSISAKGAELLI.mPPLIQEML.                                                                                                     
RRA_XENLA          SPETQDLIEKVQKAHQETFPAL.lDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKSACLDILILRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FANQPVPLEMDDAETGLLSAICLICG.qPDKVDKLQEPLLEALKIYVRTRRP.pHMFPKMLMKITDLRTVSAKGAERVI.m.PLIQEML.                                                                                                     
RRG2_XENLA         PPEMEELIQKVSKAHQETFPSL.lDLGLWDKFSELSTKCIIKIVEFAKRLPGFTTLTIADQITLLKSACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFS.FADQLLPLEMDDTETGLLSAICLICG.ePEKVEKLQEPLLEGLKFYARRRRP.pYMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
Q9DGJ6             STETEQMINRVSKAHKETFPSL.lDVNLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYT.qDTMTFSD..GLTPNRTQMHNAG..FGPLTDLVFA.FANQLLPLEMDDAETGLLSAICLLCG.qADKVDVLQEPLLEALKIYVRKRRP.pHMFPKMLMKITDLRSISAKGAERVI.mPPLIQEML.                                                                                                     
Q90968             SPALEELIQKVSRAHQETFPSL.lDPGLWDKFSELATKCIIKIVEFAKRLPGFTALSIADQITLLKAACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAGQLLPLEMDDTETGLLSAICLICG.ePEQVERLQEPLLEALRVYARRRRP.pHMFPRMLMKITDLRGISTKGAERAI.mPPLIREML.                                                                                                     
P79300             SPQLEELITKVSKLHQETFPSL.lDLGLWDKFSELVTKCIIKIVEFAKRLSGFTGLSIADQITLLKAACLDILMLRICTRYT.qDTMTVSD..GLTLNRTQMHDAD..FGPLTDLVFA.FAGQLLPLEMDDTETGLLSAICLICG.ePEKVDKLQEPLLEALRLYARRRRP.pYMFPRILMKITDLRGISTKGAERAI...........                                                                                                         
Q90273             SGELEELVNKVSKAHQETFPSL.lDLGLWDKFSELSTKCIIKIVEFAKALPGFTTLTIADQITLLKSACLDILMLRICTRYT.qDTMTFSD..GLTLNRTQMHNAG..FGPLTDLVFA.FAGQLLPLEMDDTETGLLSAICLICG.ePERVDRLQEPLLEALKIYARRRRP.pHMFPKI..............................                                                                                                     
P91780             TPEIENIVSVVAKAHLDTFPKN.vDVKLWSKFSDLSTKSIIKIVEFAKSVPGFTDLTIADQITLLKSACLEILFFRICSRYD.nDTMSFSD..GLTLNRDQLRNCA..FGPMTEQVFG.FAKSLTPFDLDHTEGGLLCAICLMCA.dPEKVEKLQEPLVEGLKWFARKKRP.pHVFPKMLMKIADLRCIGFKGGDRAM.mPPLMREMLV                                                                                                     
P91779             TPEIENIVSVVAKAHLDTFPKN.vDVKLWSKFSDLSTKSIIKIVEFAKSVPGFTDLTIADQITLLKSACLEILFFRICSRYD.nDTMSFSD..GLTLNRDQLRNCA..FGPMTEQVFG.FAKSLTPFDLDHTEGGLLCAICLMCA.dPEKVEKPQEPLVEGLKWFARKKRP.pHVFPKMLMKIADLRCIGFKGGDRAM.mPPLMREMLV                                                                                                     




Profile: hPXR (based on 3D structure) Number of sequences aligned: 7



                   137          150   156                           L341 L346         548         560         B250 B254        736            751   848        859                             1038                   1061
                    |            |     |                             |    |            |           |            |   |           |              |     |          |                               |                      |
PXR_HUMAN          TEEQRMMIRELMDAQMKTFDT..eIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVF..tGTWECG...RLSYCL.............lEPMLK.FHYMLKKLQLHEEEYVLMQAISLFS..qHRVVDQLQEQFAITLKSYIECNR..rFLFLKIMAMLTELRSINAQHTQRL..aTPLMQELF.   
                                           |                        |      |          |                |    |        |     |                    |   |                 |                     |                              |      |
                                          328                      353    447        458              B150 B155     647   653                 L781 L785              936                   958                           1245    1252                                                                                                  

Q9UNW4             TEEQRMMIRELMDAQMKTFDT..eIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVF..tGTWECG...RLSYCL.............lEPMLK.FHYMLKKLQLHEEEYVLMQAISLFS..qHRVVDQLQEQFAITLKSYIECNR..rFLFLKIMAMLTELRSINAQHTQRL..aTPLMQELF.                                                                                                     
Q9TU02             TGEQRMIIEELMDAQMKTFDT..kLFSLLPHLADMSTYMFKGIINFAKVISYFRDLPIEDQISLLKGATLELCLLRFNTVF..tGTWECG...RLSYCV.............vDPLLK.FHYMLKKLQLHKEEYVLMQAISLFS..qREVVDQLQERFA